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rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
|
28357805 |
2018 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PRR NLRC4, caspase 1 and IL1β were significantly elevated in denervated muscle of SOD1<sup>(G93A)</sup> mice and sALS patients.
|
29575052 |
2018 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice.
|
27880990 |
2018 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Inflammasome activation was recently shown in the spinal cord of human sporadic ALS patients and in the SOD1(G93A) mouse model for ALS.
|
27957680 |
2017 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we show the therapeutic benefits of a modified peptide agonist stearyl-norleucine-VIP (SNV) in a transgenic rat model of amyotrophic lateral sclerosis (mutated superoxide dismutase 1, hSOD1(G93A)).
|
25311268 |
2015 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated the expression, activation and co-localization of the NLRP3 inflammasome in the spinal cord of male SOD1(G93A) mice carrying a mutant human superoxide dismutase 1 (SOD1) variant and regarded as an animal model for ALS as well as in post-mortem tissue of ALS patients.
|
26200799 |
2015 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
|
24820540 |
2014 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS.
|
22523565 |
2012 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We show here that the expression of caspase-11 is upregulated in the spinal cord of superoxide dismutase 1 (SOD1) G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis (ALS), before the onset of motor dysfunction and remains at the high levels throughout the course of disease.
|
12843244 |
2003 |
|
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
|
12124437 |
2002 |