|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no associations of TLR4 rs11536878 and rs4986790 SNPs with RA disease activity progression.
|
25573402 |
2015 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall analyses indicated that TLR4 Asp299Gly polymorphism might contribute to RA pathogenesis.
|
25499175 |
2015 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA.
|
23325096 |
2014 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of three European studies showed no significant association between the TLR4 Asp299Gly (rs4986790) polymorphism and rheumatoid arthritis (odds ratio = 0.897, 95% confidence interval = 0.734-1.096, P = 0.289).
|
23420357 |
2013 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, results in our study do not support the hypothesis that the rs4986790 (+896A>G, Asp299Gly) TLR4 variant may influence predisposition for subclinical atherosclerosis and clinically evident CV disease in RA patients.
|
22360682 |
2012 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.
|
22717291 |
2012 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to RA in Chinese people, two functional variants, Asp299Gly and Thr399Ile, in the TLR4 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing techniques from 213 RA patients and 247 ethnically matched controls.
|
20306049 |
2010 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Mal S180L and TLR4 G299D polymorphisms do not contribute to RA susceptibility or severity either individually or in combination.
|
18180278 |
2008 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis.
|
18381796 |
2008 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether the +896 A-->G substitution of the Toll-like receptor 4 (TLR4) gene, causing the Asp299-->Gly change in the extracellular domain of TLR4, influences treatment response in recent-onset rheumatoid arthritis.
|
16606645 |
2006 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated, by using a polymerase chain reaction restriction-fragment length polymorphism method, the possible association between the polymorphisms of TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes with the susceptibility or severity of RA and SLE.
|
14651524 |
2004 |