Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 GeneticVariation BEFREE These results suggest that <i>HIF-1α</i> rs11549465 C>T polymorphism may predispose to cancer susceptibility. 31762805

2019
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 GeneticVariation BEFREE Studies on HIF 1α C1772T (P582S) polymorphism revealed a genetic susceptibility to malignant tumors, however, the results were conflicting. 24576222

2014
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 GeneticVariation BEFREE In conclusion, our findings suggest that HIF1A Pro582Ser</span> polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations. 25117331

2014
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 GeneticVariation BEFREE Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk. 24293391

2014
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 GeneticVariation BEFREE This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer. 24063654

2013
dbSNP: rs11549465
rs11549465
HIF1A ; HIF1A-AS3
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 GeneticVariation BEFREE The P582S HIF-1alpha is a stable variant and HIF-1alpha mutation is a mechanism for enhancing HIF-1alpha activity in human cancer. 15538748

2005