|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Mir-149 rs2292832 was not associated with cancer risk in overall population and there were no differences between Asians and Caucasians.
|
30930933 |
2019 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS.
|
30619739 |
2018 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, significant association between miR-149 rs2292832 and susceptibility to cancer was identified in a recessive genetic model, TT/ (TC + CC) (OR = 1.19, 95% CI = 1.02-1.39, P = 0.02).
|
30447914 |
2018 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, the results demonstrated that the rs2292832 polymorphism was subtly decrease the risk of breast cancer (CT + CC vs TT: OR = 0.83, 95% CI: 0.70-0.98, P = 0.03; CC vs CT + TT: OR = 0.80, 95% CI: 0.68-0.93, P = 0.00), and the rs895819 polymorphism wasassociated with significantly increased cancer risk in the Asian population (AG + GG vs AA: OR = 1.24, 95% CI: 1.03-1.50, P = 0.02) and in colorectal cancer subgroup (GG vs AA: OR = 1.45, 95% CI: 1.10-1.92, P = 0.00; AG + GG vs AA: OR = 1.35, 95% CI: 1.15-1.58, P = 0.00; GG vs AG + AA: OR = 1.36, 95% CI: 1.04-1.77, P = 0.02).
|
26993779 |
2016 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
When all the eligible studies were pooled into this meta-analysis, a significant association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found, while no association was found between this gene polymorphism and overall cancer risk.
|
27348444 |
2016 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
For the rs2292832 polymorphism, the results showed no significant risk association in both overall pooled analysis and subgroup of cancer types, smoking status, gender and tea drinking status in the Chinese population.
|
23725137 |
2013 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results of this meta-analysis suggest that the hsa-miR-149 rs2292832 polymorphism is not associated with cancer risk in spite of the potentially protective role of C allele in hepatocellular carcinoma and male gastric cancer.
|
24040059 |
2013 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 are risk factors for cancer development, whereas mir-149 rs2292832 and miR-27a rs895919 are not associated with cancer risk.
|
24278149 |
2013 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a rs2910164, mir-196a2 rs11614913, mir-149 rs2292832 and mir-499 rs3746444) and cancer risk by using a two-sided meta-analytic approach.
|
23226435 |
2012 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies.
|
23155448 |
2012 |
|
rs2292832
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs.
|
21902575 |
2011 |