DisGeNET - a database of gene-disease associations

Source: BEFREE

Disease: Malignant Neoplasms ×

Variant: rs752742313 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs752742313

PIK3CB

CUI:	C0006826
Disease:	Malignant Neoplasms

Malignant Neoplasms

0.010

GeneticVariation

BEFREE

This study offers evidence that personalizing treatment of ER-positive breast cancers to PI3K inhibitor therapy may benefit from an analysis of PIK3CA-E545K-AKT1-estrogen signaling pathways.Cancer Res; 76(13); 3989-4001.©2016 AACR.

27197157

2016