Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2274223
rs2274223
PLCE1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 GeneticVariation BEFREE Results of subgroup analysis showed that the rs2274223 polymorphism was associated with higher risk for esophageal cancer and gastric cancer relative to colorectal cancer and head and neck cancer. 30619753

2018
dbSNP: rs2274223
rs2274223
PLCE1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 GeneticVariation BEFREE Overall, in the present study SNPs of PSCA (rs2294008, rs2976392), MUC1 (rs4072037) and PLCE1 (rs2274223) genes were not associated with the presence of CRC. 26320491

2015
dbSNP: rs2274223
rs2274223
PLCE1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 GeneticVariation BEFREE These results indicate that the PLCE1 rs2274223 A > G change might reduce gene expression and that the variant G genotype might contribute to the increased risk of CRC. 24496148

2014
dbSNP: rs2274223
rs2274223
PLCE1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.040 GeneticVariation BEFREE The SNPs rs3765524 and rs2274223, located on 10q23, were found to have significant protective effects against C</span>RC, with equal odds ratios per allele. 22740136

2012