The pooled result showed that the <i>ICAM-1</i> gene E469K</span> polymorphism was significantly associated with an increased risk of CHD (OR = 1.20, 95% CI = 1.11-1.29, for the allele K versus allele E; OR = 1.66, 95% CI = 1.43-1.92, for the K allele carriers versus EE).
As their main finding, they concluded that 'K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD amongst Chinese and Caucasians populations'.
Intercellular adhesion molecule-1 E469K gene polymorphism and coronary artery disease in the Chinese population: a meta-analysis involving 3065 subjects.
The pooled result showed that the ICAM1 gene-E469K</span> polymorphism was significantly associated with an increased risk of CHD (OR = 1.496, 95% CI = 1.363-1.642, for the allele K vs. allele E; OR = 1.919, 95% CI = 11.635-2.253, for the K allele carriers vs. EE).