rs1217691063
|
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among these three factors, folate deficiency had the greatest contribution to the serum tHcy concentration, followed by (in order of decreasing effect) MTHFR C677T and vitamin B12 deficiency.
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28094233 |
2017 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
This computational model shows that de novo dTMP synthesis is highly sensitive to the common MTHFR C677T polymorphism and that the effect of the polymorphism on FOCM is greater in folate deficiency.
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28400561 |
2017 |
rs1217691063
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Folic Acid Deficiency
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|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive population.
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26266420 |
2015 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
The common polymorphisms of the MTHFR (C677T and A1298C), MTRR (A66G), and MTR (A2756G) enzymes are well documented as folate deficiency-related disorders, but their roles have not been examined in acromegalic patients.
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26154858 |
2015 |
rs1217691063
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|
Folic Acid Deficiency
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|
0.100 |
GeneticVariation
|
BEFREE |
Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population.
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22901194 |
2012 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate deficiency and the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism have been linked to negative symptoms in schizophrenia both independently and synergistically.
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21334854 |
2011 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate deficiency and MTHFR C677T polymorphisms have been shown to be related to DNA damage.
|
19121630 |
2009 |
rs1217691063
|
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate deficiency and the presence of the 677C > T (CT) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene have been implicated in the causation of malformations in the fetus (particularly cleft lip and palate and neural tube defects).
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17951123 |
2008 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation of the methylenetetrahydrofolate reductase gene may induce hyperhomocysteinemia and could slightly increase the risk of arterial or venous thrombosis and pregnancy loss in individuals with folic acid deficiency.
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16185908 |
2006 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes.
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16950805 |
2006 |
rs1217691063
|
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 677C > T mutation in mothers, either in a homozygous or heterozygous state, together with poor nutritional status (probable folate deficiency) may represent a risk factor for irreversible HIEN in the offspring.
|
15617551 |
2005 |
rs1217691063
|
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Folic Acid Deficiency
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|
0.100 |
GeneticVariation
|
BEFREE |
Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors.
|
15002923 |
2004 |
rs1217691063
|
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C-->T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa.
|
15051606 |
2004 |
rs1217691063
|
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, inasmuch as fewer than a third of patients with HHcy were C677T MTHFR homozygous or had vitamin B(12) or folate deficiency, other mechanisms must be responsible in the majority.
|
14603192 |
2003 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results show that the C677T polymorphism does not affect the ability of a cell to resist chromosome damage induced by folic acid deficiency in this in vitro system.
|
11588136 |
2001 |
rs1217691063
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro.
|
11408344 |
2001 |
rs1217691063
|
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Folic Acid Deficiency
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism may cause hyperhomocysteinaemia, a recognized risk factor for stroke, in individuals with folate deficiency.
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10583261 |
1999 |