rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis.
|
26345834 |
2015 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility.
|
25339039 |
2014 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility.
|
23475592 |
2014 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
Telomeres of patients with minor genotype CC of rs12951053 and GG of rs1042522 were significantly shorter compared to patients with other genotypes of this single nucleotide polymorphism in esophageal cancer tissue.
|
23124483 |
2013 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the stratified analysis by ethnicity, the data suggested that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in the Asian group.
|
23844939 |
2013 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models.
|
21448430 |
2011 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significantly associated with the Pro variant of TP53 Arg72Pro in three genetic comparison models [odds ratio (OR)Pro vs. Arg=1.21, 95% confidence interval (CI): 1.05-1.39, POR=0.009; ORDominant genetic model=1.22, 95% CI: 1.09-1.37, POR=0.001; ORHomozygote model=1.40, 95% CI: 1.05-1.87, POR=0.024].
|
20389250 |
2010 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.
|
20827430 |
2010 |
rs1042522
|
|
Malignant neoplasm of esophagus
|
|
0.090 |
GeneticVariation
|
BEFREE |
In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold increased risk of death in all esophageal cancers, whereas MDM2 T309G G/G was associated with a 7-fold increased risk of death in squamous cell carcinoma.
|
19383811 |
2009 |