|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype and T allele of MTHFR C677T may confer a protective effect on disease progression to HCC in HBV-infected individuals, especially among male patients, in a population with a high prevalence of this genetic marker.
|
28082187 |
2017 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that MTHFR C677T polymorphism is associated with increased breast cancer, gastric cancer, and hepatocellular cancer risk in Asians, is associated with increased gastric cancer, multiple myeloma, and NHL risk in Caucasians, is associated with decreased AALL risk in Caucasians, is associated with decreased CALL risk in Asians, is associated with increased breast cancer risk in Asians, is associated with decreased colon cancer risk, and is associated with decreased colorectal cancer risk in male population.
|
26081619 |
2015 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygous carriers of MTHFR C677T mutation are more susceptible to HCC, but homozygous mutations of MTHFR A1298C may play a protective role for developing HCC.
|
24316043 |
2014 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma.
|
23996892 |
2014 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the findings from our meta-analysis support the associations of MTHFR C677T and A1298C polymorphisms with HCC risk in Chinese population.
|
24385382 |
2014 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, individuals with homozygote genotype TT of MTHFR C677T have obviously increased risk of hepatocellular carcinoma.
|
24132589 |
2014 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With respect to C677T polymorphism, no significant association with HCC risk was demonstrated in overall and stratified analyses.
|
23457501 |
2013 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.
|
18945219 |
2009 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population.
|
17503006 |
2007 |
|
rs1217691063
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.
|
15033905 |
2004 |