Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs397507444
rs397507444
MTHFR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation BEFREE In the subgroup analysis, significant associations between the MTHFR A1298C polymorphism and HCC risk were found in Asians (CC vs AA: OR = 0.46, 95%CI = 0.27-0.78; CC vs AC: OR = 0.41, 95%CI = 0.24-0.71; dominant model: OR = 2.27, 95%CI = 1.33-3.86; recessive model: OR = 1.03, 95%CI = 0.86-1.24). 26662389

2015
dbSNP: rs397507444
rs397507444
MTHFR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation BEFREE Thus, the findings from our meta-analysis support the associations of MTHFR C677T and A1298C polymorphisms with HCC risk in Chinese population. 24385382

2014
dbSNP: rs397507444
rs397507444
MTHFR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation BEFREE Homozygous carriers of MTHFR C677T mutation are more susceptible to HCC, but homozygous mutations of MTHFR A1298C may play a protective role for developing HCC. 24316043

2014
dbSNP: rs397507444
rs397507444
MTHFR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation BEFREE We concluded that MTHFR A1298C polymorphism may play a protective role in the carcinogenesis of HCC. 23457501

2013
dbSNP: rs397507444
rs397507444
MTHFR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation BEFREE The MTHFR 1298A>C and the MTRR 66A>G genotypes were associated with an increased risk of HCC in this Korean population. 19035314

2008
dbSNP: rs397507444
rs397507444
MTHFR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.060 GeneticVariation BEFREE Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. 17503006

2007