Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE The <i>ERCC2</i> rs13181 A>C polymorphism and <i>XRCC3</i> rs861539 C>T polymorphism may be predictive markers for prognosis in patients with HCC. 31281357

2019
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE In overall analyses, the minor alleles of four variants, Arg280His (odds ratio, 95% confidence interval, P: 1.37, 1.13-1.66, 0.001), Thr241Met (1.93, 1.17-3.20, 0.011), Asp312Asn (1.22, 1.08-1.38, 0.001) and Lys751Gln (1.42, 1.02-1.97, 0.038), were associated with the significant risk for hepatocellular carcinoma. 27306318

2016
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Thus, XRCC3 T241M polymorphism may constitute a risk factor for HCC in the Chinese population. 26662391

2015
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Our findings suggested that the TT genotype and T allele from rs861539 genetic variants were statistically associated with HCC risk. 24307625

2014
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Subgroup analysis by ethnicity suggested that XRCC3 Thr241Met variant was assoc</span>iated with HCC risk in Chinese population, but not in Pakistani population. 23558966

2013
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE Besides, the pooled ORs indicated that the XRCC3 Thr241Met polymorphism exerted risk effect on the HCC pathogenesis among Asians. 23824570

2013
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.070 GeneticVariation BEFREE These findings support the hypothesis that the XRCC3 Thr241Met polymorphism may be associated with the risk of AFB1-related HCC among the Guangxi population. 18504145

2008