rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.
|
21561095 |
2011 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs.
|
20364130 |
2010 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers.
|
16861262 |
2007 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells.
|
16778209 |
2006 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
A global suppressor motif for p53 cancer mutants.
|
15037740 |
2004 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study.
|
15161705 |
2004 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast.
|
15308588 |
2004 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.
|
15077194 |
2004 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Comparison of p53 mutational status with mRNA and protein expression in a panel of 24 human breast carcinoma cell lines.
|
12779080 |
2003 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Loss of MDM2 expression in human head and neck squamous cell carcinomas and clinical significance.
|
11590071 |
2001 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx.
|
10754498 |
2000 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.
|
10557074 |
1999 |
rs121912654
|
|
Neoplastic Syndromes, Hereditary
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.
|
9472631 |
1998 |