Source: CLINVAR

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. 23524406

2013
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300

2013
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091

2012
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. 22743296

2012
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338

2012
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. 22773810

2012
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma. 21483012

2011
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. 19238210

2009
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Genetic predictors of MEK dependence in non-small cell lung cancer. 19010912

2008
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
dbSNP: rs113488022
rs113488022
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		T 0.750 CausalMutation CLINVAR Missense mutations of the BRAF gene in human lung adenocarcinoma. 12460919

2002