Variant | Gene | Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||||
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C | 0.720 | CausalMutation | CLINVAR | We found that the acquired MEK1-C121S mutation in BRAF-V600E mutant melanoma conferred resistance to both vemurafenib and selumetinib but not E6201. | 24448821 | 2014 |
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C | 0.720 | CausalMutation | CLINVAR | Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. | 22588879 | 2012 |
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C | 0.720 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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C | 0.720 | CausalMutation | CLINVAR | Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. | 21383288 | 2011 |
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T | 0.720 | CausalMutation | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 |
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|
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T | 0.720 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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|
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T | 0.720 | CausalMutation | CLINVAR | COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. | 21107320 | 2010 |
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T | 0.720 | CausalMutation | CLINVAR | One such mutation, MEK1(P124L), was identified in a resistant metastatic focus that emerged in a melanoma patient treated with AZD6244. | 19915144 | 2009 |
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C | 0.700 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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C | 0.700 | GeneticVariation | CLINVAR | Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. | 23569304 | 2013 |
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C | 0.700 | GeneticVariation | CLINVAR | MEK1 mutations confer resistance to MEK and B-RAF inhibition. | 19915144 | 2009 |
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G | 0.700 | CausalMutation | CLINVAR | Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. | 22588879 | 2012 |
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G | 0.700 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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|
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T | 0.700 | CausalMutation | CLINVAR | Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. | 22588879 | 2012 |
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|
|
T | 0.700 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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|
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T | 0.700 | CausalMutation | CLINVAR | MEK1 mutations confer resistance to MEK and B-RAF inhibition. | 19915144 | 2009 |
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|
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A | 0.700 | CausalMutation | CLINVAR | Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. | 23569304 | 2013 |
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|
|
A | 0.700 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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|
|
A | 0.700 | CausalMutation | CLINVAR | MEK1 mutations confer resistance to MEK and B-RAF inhibition. | 19915144 | 2009 |
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|
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T | 0.700 | CausalMutation | CLINVAR | Melanoma genome sequencing reveals frequent PREX2 mutations. | 22622578 | 2012 |
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T | 0.700 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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|
|
C | 0.700 | CausalMutation | CLINVAR | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. | 22197931 | 2011 |
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C | 0.700 | GeneticVariation | CLINVAR | Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. | 23614898 | 2013 |
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C | 0.700 | GeneticVariation | CLINVAR | MEK1 mutations confer resistance to MEK and B-RAF inhibition. | 19915144 | 2009 |
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|
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A | 0.700 | GeneticVariation | CLINVAR | MEK1 mutations confer resistance to MEK and B-RAF inhibition. | 19915144 | 2009 |