DisGeNET - a database of gene-disease associations

Source: CURATED

Disease: Malignant neoplasm of prostate ×

Gene: CHEK2 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121908698

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs121908701

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs121908702

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs137853009

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs137853010

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs137853011

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs141568342

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs143611747

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs200917541

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs540635787

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

CLINVAR

dbSNP:

rs555607708

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs560596101

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs587780189

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs587780194

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs587780194

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

Recommendations from the EGAPP Working Group: does PCA3 testing for the diagnosis and management of prostate cancer improve patient health outcomes?

24071797

2014

dbSNP:

rs587780194

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

Early detection of prostate cancer: AUA Guideline.

23659877

2013

dbSNP:

rs587780194

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

22138009

2011

dbSNP:

rs587780194

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers.

19042984

2008

dbSNP:

rs587781667

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs587781705

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs587782401

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

CLINVAR

dbSNP:

rs72552322

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

dbSNP:

rs730881701

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

CausalMutation

CLINVAR

dbSNP:

rs750984976

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

25394175

2015

dbSNP:

rs750984976

CHEK2

CUI:	C0376358
Disease:	Malignant neoplasm of prostate

Malignant neoplasm of prostate

0.700

GeneticVariation

UNIPROT

Recommendations from the EGAPP Working Group: does PCA3 testing for the diagnosis and management of prostate cancer improve patient health outcomes?

24071797

2014