Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 351
Gene Symbol: APP
APP 		P05067 amyloid beta precursor protein Enzyme modulator 384 0.422 0.846 4.7E-02 0.900 None 0.981 2446 58 1987 2020
Entrez Id: 1636
Gene Symbol: ACE
ACE 		P12821 angiotensin I converting enzyme Enzyme 979 0.328 0.923 1.0E-37 0.900 strong 0.915 85 7 1998 2020
Entrez Id: 348
Gene Symbol: APOE
APOE 		P02649 apolipoprotein E 886 0.338 0.962 1.9E-03 0.700 None 0.946 3007 20 1991 2020
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		P10636 microtubule associated protein tau 256 0.446 0.923 6.0E-03 0.700 None 0.990 958 22 1988 2020
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		P49768 presenilin 1 Enzyme 232 0.469 0.846 0.97 0.700 None 0.971 641 56 1990 2020
Entrez Id: 54209
Gene Symbol: TREM2
TREM2 		Q9NZC2 triggering receptor expressed on myeloid cells 2 119 0.519 0.769 3.3E-09 0.700 limited 0.977 211 13 2007 2020
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B 		P49841 glycogen synthase kinase 3 beta Kinase 338 0.430 0.846 0.96 0.700 None 0.982 104 3 2000 2020
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10 		O14672 ADAM metallopeptidase domain 10 202 0.489 0.846 1.00 0.700 None 0.986 68 7 2000 2019
Entrez Id: 3077
Gene Symbol: HFE
HFE 		Q30201 homeostatic iron regulator 310 0.436 0.846 2.6E-08 0.700 strong 0.963 25 3 2001 2018
Entrez Id: 5328
Gene Symbol: PLAU
PLAU 		P00749 plasminogen activator, urokinase Enzyme 301 0.425 0.923 2.3E-06 0.680 None 1.000 7 1 2002 2013
Entrez Id: 23621
Gene Symbol: BACE1
BACE1 		P56817 beta-secretase 1 Enzyme 108 0.559 0.769 0.88 0.600 None 0.985 463 4 1999 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		P23560 brain derived neurotrophic factor Signaling 852 0.345 0.923 0.66 0.600 None 0.958 237 10 1991 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		P01584 interleukin 1 beta 1604 0.276 0.962 0.13 0.600 None 0.966 112 0 1989 2020
Entrez Id: 3416
Gene Symbol: IDE
IDE 		P14735 insulin degrading enzyme Enzyme 59 0.604 0.577 6.6E-03 0.600 None 0.955 83 9 2000 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		P42574 caspase 3 Enzyme 722 0.351 0.923 0.10 0.600 None 0.980 45 2 1999 2020
Entrez Id: 3952
Gene Symbol: LEP
LEP 		P41159 leptin 807 0.349 0.846 0.46 0.600 None 0.944 34 0 2004 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR 		P06213 insulin receptor Kinase 288 0.432 0.846 3.6E-05 0.600 None 1.000 32 0 2002 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		P10415 BCL2 apoptosis regulator Signaling 1294 0.291 0.885 0.56 0.600 None 1.000 26 1 1996 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY 		P01303 neuropeptide Y Signaling 289 0.447 0.846 0.14 0.600 None 0.833 10 0 2000 2018
Entrez Id: 3481
Gene Symbol: IGF2
IGF2 		P01344 insulin like growth factor 2 477 0.390 0.885 4.4E-02 0.570 None 1.000 7 0 2002 2019
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R 		P08069 insulin like growth factor 1 receptor Kinase 422 0.399 0.885 0.97 0.560 None 1.000 6 0 2005 2020
Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A 		P25705 ATP synthase F1 subunit alpha Transporter 45 0.604 0.731 1.00 0.540 None 1.000 3 0 2003 2017
Entrez Id: 3630
Gene Symbol: INS
INS 		P01308 insulin 202 0.445 0.923 0.30 0.530 None 1.000 2 0 1991 2020
Entrez Id: 581
Gene Symbol: BAX
BAX 		Q07812 BCL2 associated X, apoptosis regulator Signaling 338 0.417 0.885 0.32 0.520 None 1.000 2 0 1997 2018
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		P49810 presenilin 2 Enzyme 97 0.550 0.654 5.4E-04 0.500 None 0.977 166 12 1995 2020