Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 826 0.333 0.923 0.84 0.310 None 1.000 1 0 2007 2009
Entrez Id: 182
Gene Symbol: JAG1
JAG1 		P78504 jagged canonical Notch ligand 1 322 0.429 0.808 1.00 0.310 None 1.000 1 0 1997 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 972 0.324 0.962 1.00 0.310 None 1.000 1 0 2006 2017
Entrez Id: 59341
Gene Symbol: TRPV4
TRPV4 		Q9HBA0 transient receptor potential cation channel subfamily V member 4 Ion channel 207 0.457 0.808 2.2E-16 0.310 None 1.000 1 0 2011 2016
Entrez Id: 650
Gene Symbol: BMP2
BMP2 		P12643 bone morphogenetic protein 2 Signaling 313 0.432 0.846 0.99 0.310 None 1.000 1 0 2012 2017
Entrez Id: 1490
Gene Symbol: CCN2
CCN2 		P29279 cellular communication network factor 2 Signaling 444 0.399 0.846 5.0E-04 0.210 None 0.500 1 0 2000 2007
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11 		O14788 TNF superfamily member 11 Signaling 253 0.453 0.846 4.9E-03 0.100 None 1.000 30 0 2002 2020
Entrez Id: 50964
Gene Symbol: SOST
SOST 		Q9BQB4 sclerostin 187 0.474 0.808 0.87 0.100 None 0.960 25 0 2005 2019
Entrez Id: 5741
Gene Symbol: PTH
PTH 		P01270 parathyroid hormone 507 0.397 0.846 1.2E-02 0.100 None 1.000 21 0 2001 2020
Entrez Id: 22943
Gene Symbol: DKK1
DKK1 		O94907 dickkopf WNT signaling pathway inhibitor 1 315 0.439 0.885 0.17 0.100 None 1.000 20 0 2006 2019
Entrez Id: 4982
Gene Symbol: TNFRSF11B
TNFRSF11B 		O00300 TNF receptor superfamily member 11b 369 0.422 0.808 0.16 0.100 None 1.000 16 0 2001 2020
Entrez Id: 8074
Gene Symbol: FGF23
FGF23 		Q9GZV9 fibroblast growth factor 23 Signaling 281 0.460 0.731 3.1E-02 0.100 None 0.938 16 0 2012 2020
Entrez Id: 860
Gene Symbol: RUNX2
RUNX2 		Q13950 RUNX family transcription factor 2 Transcription factor 287 0.437 0.846 0.95 0.100 None 1.000 14 0 1997 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6 		P05231 interleukin 6 2132 0.248 0.962 0.32 0.100 None 1.000 10 0 1994 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF 		P01375 tumor necrosis factor Signaling 2475 0.231 0.962 0.80 0.100 None 0.800 10 0 2005 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		P01584 interleukin 1 beta 1604 0.276 0.962 0.13 0.080 None 1.000 8 0 2003 2020
Entrez Id: 7421
Gene Symbol: VDR
VDR 		P11473 vitamin D receptor Nuclear receptor 757 0.352 0.885 1.7E-05 0.070 None 1.000 7 0 2006 2018
Entrez Id: 4041
Gene Symbol: LRP5
LRP5 		O75197 LDL receptor related protein 5 147 0.485 0.846 0.51 0.070 None 1.000 6 0 2003 2018
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		Q9Y6Q6 TNF receptor superfamily member 11a 196 0.480 0.846 8.8E-03 0.060 None 1.000 6 0 2012 2019
Entrez Id: 249
Gene Symbol: ALPL
ALPL 		P05186 alkaline phosphatase, biomineralization associated Enzyme 89 0.546 0.769 3.6E-04 0.050 None 1.000 5 1 2000 2019
Entrez Id: 8740
Gene Symbol: TNFSF14
TNFSF14 		O43557 TNF superfamily member 14 Signaling 137 0.529 0.769 5.2E-02 0.050 None 1.000 5 0 2014 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		P10451 secreted phosphoprotein 1 715 0.353 0.885 2.1E-06 0.050 None 1.000 4 0 2007 2020
Entrez Id: 3082
Gene Symbol: HGF
HGF 		P14210 hepatocyte growth factor Enzyme 584 0.374 0.885 1.00 0.040 None 1.000 4 0 2007 2019
Entrez Id: 1513
Gene Symbol: CTSK
CTSK 		P43235 cathepsin K Enzyme 162 0.497 0.808 3.1E-05 0.040 None 1.000 4 0 1999 2018
Entrez Id: 6348
Gene Symbol: CCL3
CCL3 		P10147 C-C motif chemokine ligand 3 Signaling 241 0.460 0.885 0.35 0.040 None 1.000 4 0 2005 2016