Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		P31749 AKT serine/threonine kinase 1 Kinase 1250 0.311 0.962 0.98 0.600 limited 0.984 123 1 2002 2020
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 297 0.460 0.808 1.2E-24 0.700 limited 0.885 26 5 2003 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 526 0.399 0.808 3.4E-05 0.800 strong 0.973 485 32 1993 2020
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 703 0.373 0.962 1.00 0.800 strong 0.972 359 34 1990 2020
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 490 0.406 0.808 0.90 0.800 strong 0.971 277 18 1993 2020
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH 		Q9UIF7 mutY DNA glycosylase Enzyme 156 0.521 0.769 1.3E-18 0.500 strong 0.947 132 20 2002 2019
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		P52701 mutS homolog 6 Nucleic acid binding 296 0.462 0.731 3.7E-05 0.600 strong 0.974 114 36 1988 2020
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		Q13485 SMAD family member 4 Transcription factor 575 0.401 0.808 1.00 0.700 strong 0.981 103 3 1996 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 1349 0.305 0.923 0.26 0.400 strong 0.964 83 4 2000 2019
Entrez Id: 5395
Gene Symbol: PMS2
PMS2 		P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 244 0.484 0.808 4.5E-27 0.500 strong 0.967 60 6 1998 2020
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 611 0.390 0.808 0.49 0.800 strong 0.966 59 6 1993 2020
Entrez Id: 5426
Gene Symbol: POLE
POLE 		Q07864 DNA polymerase epsilon, catalytic subunit 151 0.526 0.731 8.0E-27 0.600 strong 1.000 28 5 2013 2020
Entrez Id: 5424
Gene Symbol: POLD1
POLD1 		P28340 DNA polymerase delta 1, catalytic subunit 189 0.507 0.769 2.4E-06 0.600 strong 0.944 18 3 1995 2020
Entrez Id: 6794
Gene Symbol: STK11
STK11 		Q15831 serine/threonine kinase 11 Kinase 372 0.435 0.808 0.99 0.600 strong 1.000 14 5 1998 2019
Entrez Id: 4913
Gene Symbol: NTHL1
NTHL1 		P78549 nth like DNA glycosylase 1 Enzyme 57 0.623 0.615 5.7E-10 0.390 strong 1.000 9 1 2006 2019
Entrez Id: 657
Gene Symbol: BMPR1A
BMPR1A 		P36894 bone morphogenetic protein receptor type 1A Kinase 203 0.522 0.731 0.90 0.340 strong 1.000 4 0 2015 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 1213 0.320 0.923 7.9E-04 0.600 None 0.963 1007 13 1990 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2494 0.236 0.962 0.53 0.700 None 0.947 665 19 1989 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1228 0.319 0.846 1.00 0.700 None 0.976 622 10 2002 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1394 0.295 0.885 0.37 0.400 None 0.991 568 12 1992 2020
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1368 0.303 0.885 1.00 0.700 None 0.983 469 8 1997 2020
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5 		P06731 CEA cell adhesion molecule 5 428 0.420 0.846 4.2E-10 0.100 None 0.990 288 0 1986 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1511 0.292 0.923 1.00 0.700 None 0.985 266 13 2002 2020
Entrez Id: 4360
Gene Symbol: MRC1
MRC1 		P22897 mannose receptor C-type 1 431 0.413 0.846 0.94 0.100 None 0.951 247 1 1995 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1234 0.314 0.962 1.00 0.400 None 0.979 243 11 1994 2020