Source: INFERRED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 187 0.373 0.962 1.00 0.800 strong 0.972 6 14 1990 2020
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 95 0.399 0.808 3.4E-05 0.800 strong 0.973 3 2 1993 2020
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 97 0.406 0.808 0.90 0.800 strong 0.971 0 2 1993 2020
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 216 0.390 0.808 0.49 0.800 strong 0.966 0 1 1993 2020
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		Q9NQB0 transcription factor 7 like 2 58 0.485 0.846 1.00 0.700 None 0.925 5 2 1999 2019
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3 		P84022 SMAD family member 3 Transcription factor 137 0.415 0.923 0.80 0.700 None 0.941 1 1 1998 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 94 0.333 0.923 0.84 0.700 None 1.000 1 1 1992 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 342 0.319 0.846 1.00 0.700 None 0.976 0 5 2002 2020
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 79 0.460 0.808 1.2E-24 0.700 limited 0.885 0 1 2003 2019
Entrez Id: 699
Gene Symbol: BUB1
BUB1 		O43683 BUB1 mitotic checkpoint serine/threonine kinase Kinase 67 0.528 0.731 4.9E-09 0.700 None 1.000 0 1 2000 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 221 0.236 0.962 0.53 0.700 None 0.947 0 7 1989 2020
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 191 0.303 0.885 1.00 0.700 None 0.983 0 3 1997 2020
Entrez Id: 1630
Gene Symbol: DCC
DCC 		P43146 DCC netrin 1 receptor 96 0.471 0.808 0.99 0.700 None 0.946 0 1 1990 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 283 0.292 0.923 1.00 0.700 None 0.985 0 5 2002 2020
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3 		P22607 fibroblast growth factor receptor 3 Kinase 307 0.391 0.846 1.6E-05 0.660 None 1.000 0 8 2000 2018
Entrez Id: 688
Gene Symbol: KLF5
KLF5 		Q13887 Kruppel like factor 5 Nucleic acid binding 12 0.534 0.769 0.82 0.640 None 1.000 2 1 2011 2019
Entrez Id: 2033
Gene Symbol: EP300
EP300 		Q09472 E1A binding protein p300 160 0.459 0.846 1.00 0.640 None 1.000 1 4 1996 2017
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH 		Q9UIF7 mutY DNA glycosylase Enzyme 24 0.521 0.769 1.3E-18 0.500 strong 0.947 22 9 2002 2019
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7 		O15105 SMAD family member 7 Transcription factor 22 0.470 0.769 0.55 0.500 None 0.984 18 8 2001 2019
Entrez Id: 26585
Gene Symbol: GREM1
GREM1 		O60565 gremlin 1, DAN family BMP antagonist 25 0.508 0.808 0.47 0.500 None 0.957 6 4 2003 2019
Entrez Id: 652
Gene Symbol: BMP4
BMP4 		P12644 bone morphogenetic protein 4 Signaling 78 0.422 0.808 0.96 0.500 None 0.952 2 1 2008 2020
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 74 0.401 0.808 0.15 0.500 None 0.939 2 2 1997 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		P01137 transforming growth factor beta 1 Signaling 107 0.287 0.962 3.7E-02 0.500 None 0.971 1 2 1995 2020
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 135 0.358 0.885 2.9E-02 0.500 None 0.938 0 4 2000 2019
Entrez Id: 5395
Gene Symbol: PMS2
PMS2 		P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 95 0.484 0.808 4.5E-27 0.500 strong 0.967 0 1 1998 2020