Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.900 None 0.946 188 10 1991 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1 		O75874 isocitrate dehydrogenase (NADP(+)) 1 348 0.424 0.808 2.6E-12 0.700 None 0.984 367 3 2008 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.700 None 0.972 103 1 1997 2020
Entrez Id: 1030
Gene Symbol: CDKN2B
CDKN2B 		P42772 cyclin dependent kinase inhibitor 2B 382 0.417 0.769 7.3E-03 0.700 None 0.882 15 2 1995 2019
Entrez Id: 4683
Gene Symbol: NBN
NBN 		O60934 nibrin Nucleic acid binding 212 0.467 0.808 2.2E-16 0.620 strong 1.000 2 1 2016 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 1214 0.300 0.885 0.39 0.600 None 0.936 73 2 1994 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.600 None 1.000 32 2 2005 2020
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		P10451 secreted phosphoprotein 1 715 0.353 0.885 2.1E-06 0.600 None 1.000 16 0 1995 2019
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 563 0.374 0.885 5.6E-47 0.600 strong 0.938 15 1 2001 2019
Entrez Id: 4763
Gene Symbol: NF1
NF1 		P21359 neurofibromin 1 Enzyme modulator 236 0.440 0.885 0.90 0.580 None 1.000 8 0 1994 2019
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 457 0.378 0.885 8.0E-02 0.520 None 1.000 2 0 2000 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.500 None 0.991 204 10 1988 2020
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1 		Q9NZ71 regulator of telomere elongation helicase 1 Enzyme 202 0.459 0.808 8.9E-10 0.500 None 1.000 24 4 2009 2020
Entrez Id: 23187
Gene Symbol: PHLDB1
PHLDB1 		Q86UU1 pleckstrin homology like domain family B member 1 12 0.722 0.423 0.11 0.500 None 1.000 16 4 2009 2020
Entrez Id: 137196
Gene Symbol: CCDC26
CCDC26 		Q8TAB7 CCDC26 long non-coding RNA 29 0.647 0.615 0.500 None 1.000 14 4 2009 2020
Entrez Id: 4255
Gene Symbol: MGMT
MGMT 		P16455 O-6-methylguanine-DNA methyltransferase 408 0.412 0.885 1.2E-07 0.400 None 0.980 95 6 1991 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.400 None 1.000 70 0 1998 2020
Entrez Id: 7015
Gene Symbol: TERT
TERT 		O14746 telomerase reverse transcriptase Enzyme 525 0.374 0.846 0.99 0.400 None 0.979 45 4 2004 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF 		P01375 tumor necrosis factor Signaling 2475 0.231 0.962 0.80 0.400 None 1.000 42 0 1993 2020
Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1 		P18887 X-ray repair cross complementing 1 369 0.421 0.923 6.3E-09 0.400 None 0.893 27 9 2007 2019
Entrez Id: 546
Gene Symbol: ATRX
ATRX 		P46100 ATRX chromatin remodeler 171 0.452 0.808 1.00 0.400 None 1.000 24 0 2012 2020
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1043 0.314 0.962 1.00 0.400 None 0.920 24 2 2001 2019
Entrez Id: 2247
Gene Symbol: FGF2
FGF2 		P09038 fibroblast growth factor 2 Signaling 546 0.383 0.923 1.8E-02 0.400 None 1.000 21 0 1993 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		Q00987 MDM2 proto-oncogene Nucleic acid binding 669 0.362 0.846 1.00 0.400 None 0.958 21 1 1994 2019
Entrez Id: 648
Gene Symbol: BMI1
BMI1 		P35226 BMI1 proto-oncogene, polycomb ring finger 293 0.448 0.808 0.94 0.400 None 1.000 19 0 2008 2018