Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		P35555 fibrillin 1 Calcium-binding protein 259 0.417 0.846 1.00 1.000 definitive 0.986 389 20 1973 2020
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2 		P37173 transforming growth factor beta receptor 2 Kinase 307 0.413 0.846 0.13 0.500 None 1.000 33 2 1994 2019
Entrez Id: 4053
Gene Symbol: LTBP2
LTBP2 		Q14767 latent transforming growth factor beta binding protein 2 Calcium-binding protein 65 0.572 0.692 7.4E-04 0.410 limited 1.000 1 2 2012 2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		P35228 nitric oxide synthase 2 572 0.364 0.923 4.0E-15 0.310 None 1.000 1 0 2014 2017
Entrez Id: 875
Gene Symbol: CBS
CBS 		P0DN79 P35520 cystathionine beta-synthase Enzyme 212 0.465 0.885 3.1E-05 0.310 None 1.000 1 0 2009 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 826 0.333 0.923 0.84 0.310 None 1.000 1 0 2006 2008
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		P14780 matrix metallopeptidase 9 Enzyme 1160 0.305 0.923 1.9E-17 0.310 None 1.000 1 0 2008 2019
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1 		P36897 transforming growth factor beta receptor 1 Kinase 226 0.451 0.885 0.85 0.200 None 1.000 17 0 2006 2019
Entrez Id: 2201
Gene Symbol: FBN2
FBN2 		P35556 fibrillin 2 Calcium-binding protein 134 0.505 0.808 1.00 0.200 None 1.000 10 0 1993 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		P01137 transforming growth factor beta 1 Signaling 1334 0.287 0.962 3.7E-02 0.100 None 0.917 11 0 2003 2019
Entrez Id: 2006
Gene Symbol: ELN
ELN 		P15502 elastin 302 0.415 0.885 2.1E-14 0.100 None 1.000 11 0 1990 2019
Entrez Id: 1950
Gene Symbol: EGF
EGF 		P01133 epidermal growth factor 717 0.357 0.923 8.5E-17 0.100 None 1.000 10 0 1992 2013
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1 		P30556 angiotensin II receptor type 1 G-protein coupled receptor 381 0.423 0.846 5.3E-04 0.080 None 0.875 8 0 2008 2019
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2 		P08123 collagen type I alpha 2 chain 148 0.486 0.846 1.00 0.060 None 1.000 6 0 1985 1990
Entrez Id: 183
Gene Symbol: AGT
AGT 		P01019 angiotensinogen Enzyme modulator 632 0.367 0.923 5.0E-08 0.050 None 1.000 5 0 2009 2019
Entrez Id: 1634
Gene Symbol: DCN
DCN 		P07585 decorin 276 0.457 0.808 0.31 0.040 None 1.000 4 0 1990 1993
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2 		P61812 transforming growth factor beta 2 Signaling 301 0.433 0.885 1.00 0.040 None 1.000 4 0 2012 2018
Entrez Id: 4087
Gene Symbol: SMAD2
SMAD2 		Q15796 SMAD family member 2 Transcription factor 272 0.456 0.808 1.00 0.030 None 1.000 3 0 2018 2019
Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1 		P02461 collagen type III alpha 1 chain 115 0.477 0.808 1.00 0.030 None 1.000 3 0 1987 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		P01375 tumor necrosis factor Signaling 2475 0.231 0.962 0.80 0.020 None 1.000 2 0 2016 2018
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3 		P84022 SMAD family member 3 Transcription factor 334 0.415 0.923 0.80 0.020 None 1.000 2 0 2015 2018
Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1 		Q9UHI8 ADAM metallopeptidase with thrombospondin type 1 motif 1 Enzyme 99 0.555 0.654 0.72 0.020 None 1.000 2 0 2017 2017
Entrez Id: 59
Gene Symbol: ACTA2
ACTA2 		P62736 actin alpha 2, smooth muscle Cellular structure 105 0.508 0.846 0.93 0.020 None 1.000 2 0 2011 2014
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		P28482 mitogen-activated protein kinase 1 Kinase 935 0.330 0.923 1.00 0.020 None 1.000 2 0 2017 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 698 0.358 0.885 2.9E-02 0.020 None 1.000 2 0 2002 2017