Source: CURATED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 115 0.319 0.846 1.00 1.000 None 0.983 24 31 1986 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 182 0.305 0.923 0.26 0.800 strong 0.950 5 3 1997 2020
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 115 0.300 0.885 0.39 0.800 strong 0.950 2 6 1994 2020
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 120 0.378 0.885 8.0E-02 0.800 None 1.000 1 2 1984 2018
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 67 0.390 0.808 0.49 0.700 None 0.969 6 10 1987 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 232 0.236 0.962 0.53 0.700 None 0.943 4 0 1991 2020
Entrez Id: 7015
Gene Symbol: TERT
TERT 		O14746 telomerase reverse transcriptase Enzyme 72 0.374 0.846 0.99 0.700 strong 1.000 2 1 2001 2019
Entrez Id: 4286
Gene Symbol: MITF
MITF 		O75030 melanocyte inducing transcription factor 37 0.499 0.808 0.98 0.700 None 0.974 1 0 2002 2020
Entrez Id: 2776
Gene Symbol: GNAQ
GNAQ 		P50148 G protein subunit alpha q Enzyme modulator 18 0.516 0.808 0.98 0.700 None 0.967 1 1 1989 2019
Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4 		Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 20 0.455 0.846 1.00 0.700 None 0.917 1 6 2009 2018
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1 		Q02750 mitogen-activated protein kinase kinase 1 Kinase 30 0.439 0.846 0.90 0.700 None 1.000 1 14 2003 2019
Entrez Id: 2767
Gene Symbol: GNA11
GNA11 		P29992 G protein subunit alpha 11 Enzyme modulator 15 0.563 0.731 0.89 0.700 None 1.000 1 1 1989 2019
Entrez Id: 8314
Gene Symbol: BAP1
BAP1 		Q92560 BRCA1 associated protein 1 Enzyme 108 0.454 0.731 0.99 0.700 strong 0.950 0 1 2010 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11 		Q15831 serine/threonine kinase 11 Kinase 39 0.435 0.808 0.99 0.700 None 1.000 0 4 1999 2018
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		P11802 cyclin dependent kinase 4 Kinase 37 0.412 0.808 6.3E-02 0.700 strong 0.961 0 1 1994 2020
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2 		P36507 mitogen-activated protein kinase kinase 2 Kinase 17 0.534 0.731 0.97 0.670 None 1.000 1 5 2011 2019
Entrez Id: 4763
Gene Symbol: NF1
NF1 		P21359 neurofibromin 1 Enzyme modulator 77 0.440 0.885 0.90 0.600 None 1.000 2 0 1993 2018
Entrez Id: 5879
Gene Symbol: RAC1
RAC1 		P63000 Rac family small GTPase 1 Enzyme modulator 25 0.429 0.962 0.76 0.600 None 1.000 1 0 2004 2019
Entrez Id: 5537
Gene Symbol: PPP6C
PPP6C 		O00743 protein phosphatase 6 catalytic subunit 4 0.729 0.231 0.86 0.540 None 1.000 1 0 2012 2015
Entrez Id: 7299
Gene Symbol: TYR
TYR 		P14679 tyrosinase Enzyme 19 0.473 0.808 5.0E-32 0.500 None 0.984 4 3 1988 2019
Entrez Id: 4157
Gene Symbol: MC1R
MC1R 		Q01726 melanocortin 1 receptor G-protein coupled receptor 19 0.524 0.808 8.1E-11 0.500 None 0.959 3 1 1996 2020
Entrez Id: 51151
Gene Symbol: SLC45A2
SLC45A2 		Q9UMX9 solute carrier family 45 member 2 Transporter 18 0.626 0.538 1.7E-06 0.500 None 0.950 2 3 1996 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		Q00987 MDM2 proto-oncogene Nucleic acid binding 25 0.362 0.846 1.00 0.500 None 1.000 1 0 1995 2020
Entrez Id: 142
Gene Symbol: PARP1
PARP1 		P09874 poly(ADP-ribose) polymerase 1 62 0.389 0.923 3.3E-04 0.500 None 1.000 1 1 2006 2019
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 72 0.374 0.885 5.6E-47 0.500 None 1.000 1 2 2007 2019