Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11 		Q06124 protein tyrosine phosphatase non-receptor type 11 702 0.385 0.923 1.00 1.000 definitive 0.987 301 58 2001 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 1213 0.320 0.923 7.9E-04 1.000 definitive 0.985 68 17 1993 2019
Entrez Id: 6654
Gene Symbol: SOS1
SOS1 		Q07889 SOS Ras/Rac guanine nucleotide exchange factor 1 Enzyme modulator 261 0.485 0.808 1.00 1.000 definitive 0.969 64 23 1991 2019
Entrez Id: 5894
Gene Symbol: RAF1
RAF1 		P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 470 0.418 0.885 0.85 1.000 definitive 1.000 59 19 1992 2019
Entrez Id: 6016
Gene Symbol: RIT1
RIT1 		Q92963 Ras like without CAAX 1 Enzyme modulator 184 0.527 0.808 0.13 0.900 definitive 1.000 22 13 2013 2019
Entrez Id: 8216
Gene Symbol: LZTR1
LZTR1 		Q8N653 leucine zipper like transcription regulator 1 152 0.547 0.808 1.0E-92 0.900 strong 1.000 14 1 2014 2020
Entrez Id: 8036
Gene Symbol: SHOC2
SHOC2 		Q9UQ13 SHOC2 leucine rich repeat scaffold protein 97 0.593 0.769 1.00 0.800 disputed 0.957 23 1 2009 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 611 0.390 0.808 0.49 0.780 definitive 1.000 21 4 2000 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1228 0.319 0.846 1.00 0.770 moderate 1.000 34 18 2003 2019
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1 		Q02750 mitogen-activated protein kinase kinase 1 Kinase 389 0.439 0.846 0.90 0.680 limited 1.000 14 3 2007 2019
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2 		P36507 mitogen-activated protein kinase kinase 2 Kinase 177 0.534 0.731 0.97 0.640 limited 1.000 11 2 2007 2019
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 698 0.378 0.885 8.0E-02 0.640 1.000 8 4 2006 2018
Entrez Id: 6655
Gene Symbol: SOS2
SOS2 		Q07890 SOS Ras/Rho guanine nucleotide exchange factor 2 Enzyme modulator 92 0.608 0.692 1.00 0.620 moderate 1.000 4 0 2000 2015
Entrez Id: 22800
Gene Symbol: RRAS2
RRAS2 		P62070 RAS related 2 Enzyme modulator 48 0.656 0.500 0.97 0.620 strong 1.000 3 0 2014 2019
Entrez Id: 144568
Gene Symbol: A2ML1
A2ML1 		A8K2U0 alpha-2-macroglobulin like 1 Enzyme modulator 94 0.590 0.692 1.6E-34 0.600 disputed 1.000 3 0 2015 2016
Entrez Id: 22808
Gene Symbol: MRAS
MRAS 		O14807 muscle RAS oncogene homolog Enzyme modulator 113 0.590 0.731 0.92 0.560 limited 1.000 8 1 2013 2019
Entrez Id: 6237
Gene Symbol: RRAS
RRAS 		P10301 RAS related Enzyme modulator 149 0.543 0.808 4.7E-03 0.510 limited 1.000 2 1 2013 2014
Entrez Id: 5922
Gene Symbol: RASA2
RASA2 		Q15283 RAS p21 protein activator 2 Enzyme modulator 116 0.579 0.769 7.4E-31 0.510 limited 1.000 1 0 2014 2014
Entrez Id: 867
Gene Symbol: CBL
CBL 		P22681 Cbl proto-oncogene Enzyme 172 0.527 0.769 6.1E-04 0.460 strong 1.000 16 4 2009 2016
Entrez Id: 4763
Gene Symbol: NF1
NF1 		P21359 neurofibromin 1 Enzyme modulator 380 0.440 0.885 0.90 0.350 strong 1.000 6 3 1993 2013
Entrez Id: 5500
Gene Symbol: PPP1CB
PPP1CB 		P62140 protein phosphatase 1 catalytic subunit beta Enzyme 105 0.601 0.577 1.00 0.350 1.000 5 0 2016 2019
Entrez Id: 1969
Gene Symbol: EPHA2
EPHA2 		P29317 EPH receptor A2 Kinase 187 0.501 0.731 1.1E-05 0.310 None 1.000 2 0 2012 2013
Entrez Id: 23522
Gene Symbol: KAT6B
KAT6B 		Q8WYB5 lysine acetyltransferase 6B Enzyme 208 0.525 0.731 1.00 0.310 None 1.000 1 0 2011 2011
Entrez Id: 5921
Gene Symbol: RASA1
RASA1 		P20936 RAS p21 protein activator 1 Enzyme modulator 237 0.481 0.885 1.00 0.300 disputed 1.000 1 0 2016 2016
Entrez Id: 545
Gene Symbol: ATR
ATR 		Q13535 ATR serine/threonine kinase Kinase 321 0.456 0.923 3.5E-09 0.200 None 0 0