Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.900 None 0.971 1178 43 1982 2020
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 972 0.324 0.962 1.00 0.700 None 0.968 2989 40 1981 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 576 0.367 0.923 9.2E-29 0.700 None 0.955 2673 102 1992 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 459 0.379 0.846 2.4E-25 0.700 None 0.950 1462 46 1994 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.700 None 0.987 515 8 2001 2020
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		P31749 AKT serine/threonine kinase 1 Kinase 1011 0.311 0.962 0.98 0.700 None 0.992 260 7 1999 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.700 None 0.966 234 7 1997 2020
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 220 0.460 0.808 1.2E-24 0.700 None 0.952 162 18 2001 2019
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 87 0.485 0.769 3.0E-19 0.700 None 0.961 150 19 2007 2020
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1 		Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 72 0.507 0.731 6.2E-17 0.700 None 0.950 60 9 2003 2020
Entrez Id: 841
Gene Symbol: CASP8
CASP8 		Q14790 caspase 8 Enzyme 389 0.404 0.923 3.7E-06 0.700 None 0.980 46 10 2004 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.700 None 0.950 40 3 1987 2020
Entrez Id: 4853
Gene Symbol: NOTCH2
NOTCH2 		Q04721 notch receptor 2 202 0.441 0.808 1.00 0.680 None 1.000 8 0 2004 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 942 0.328 0.923 6.0E-03 0.600 None 0.972 4094 24 1987 2020
Entrez Id: 3169
Gene Symbol: FOXA1
FOXA1 		P55317 forkhead box A1 Transcription factor 132 0.522 0.731 0.22 0.600 None 0.986 69 0 2004 2019
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1 		P46531 notch receptor 1 581 0.369 0.885 1.00 0.600 None 1.000 60 1 2004 2020
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		P46527 cyclin dependent kinase inhibitor 1B 373 0.409 0.769 0.62 0.600 None 0.965 56 2 1996 2019
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		P03956 matrix metallopeptidase 1 Enzyme 507 0.385 0.885 7.7E-18 0.600 None 0.959 47 0 2000 2019
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1 		P11362 fibroblast growth factor receptor 1 Kinase 470 0.362 0.885 1.00 0.600 None 0.977 43 1 1994 2020
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 457 0.378 0.885 8.0E-02 0.600 None 0.919 33 0 1986 2016
Entrez Id: 2248
Gene Symbol: FGF3
FGF3 		P11487 fibroblast growth factor 3 Signaling 139 0.505 0.808 9.3E-05 0.600 None 0.968 30 0 1989 2015
Entrez Id: 5925
Gene Symbol: RB1
RB1 		P06400 RB transcriptional corepressor 1 Nucleic acid binding 220 0.444 0.885 1.00 0.600 None 0.962 23 4 1989 2020
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		P31751 AKT serine/threonine kinase 2 Kinase 218 0.474 0.769 0.64 0.600 None 1.000 21 0 1995 2019
Entrez Id: 8314
Gene Symbol: BAP1
BAP1 		Q92560 BRCA1 associated protein 1 Enzyme 203 0.454 0.731 0.99 0.600 None 1.000 18 0 1998 2019
Entrez Id: 6926
Gene Symbol: TBX3
TBX3 		O15119 T-box transcription factor 3 Transcription factor 90 0.525 0.769 0.99 0.600 None 0.929 13 3 2004 2017