Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.700 None 0.980 254 4 1985 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.700 None 1.000 37 5 2002 2019
Entrez Id: 2067
Gene Symbol: ERCC1
ERCC1 		P07992 ERCC excision repair 1, endonuclease non-catalytic subunit Enzyme 250 0.445 0.846 1.6E-07 0.600 None 0.949 38 11 2005 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.500 None 0.985 1299 31 1988 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.500 None 0.942 555 33 1989 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.500 None 0.972 105 2 2002 2019
Entrez Id: 8626
Gene Symbol: TP63
TP63 		Q9H3D4 tumor protein p63 Transcription factor 553 0.362 0.769 1.00 0.500 None 0.958 21 4 1999 2019
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 323 0.431 0.846 6.9E-07 0.500 moderate 1.000 12 6 2011 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 459 0.379 0.846 2.4E-25 0.500 None 0.846 11 2 2000 2018
Entrez Id: 2074
Gene Symbol: ERCC6
ERCC6 		P0DP91 Q03468 ERCC excision repair 6, chromatin remodeling factor 79 0.507 0.808 5.2E-22 0.430 limited 1.000 3 4 2000 2009
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 942 0.328 0.923 6.0E-03 0.400 None 0.972 107 5 1989 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.400 None 0.979 47 1 1985 2019
Entrez Id: 2042
Gene Symbol: EPHA3
EPHA3 		P29320 EPH receptor A3 Kinase 182 0.497 0.692 1.2E-05 0.350 None 1.000 5 0 1999 2018
Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2 		Q16620 neurotrophic receptor tyrosine kinase 2 Kinase 157 0.479 0.808 1.00 0.350 None 1.000 5 0 2013 2019
Entrez Id: 253260
Gene Symbol: RICTOR
RICTOR 		Q6R327 RPTOR independent companion of MTOR complex 2 77 0.592 0.615 1.00 0.330 None 1.000 3 0 2015 2017
Entrez Id: 283106
Gene Symbol: CSNK2A3
CSNK2A3 		Q8NEV1 casein kinase 2 alpha 3 Kinase 6 0.821 0.077 2.1E-10 0.310 None 1.000 1 0 2010 2010
Entrez Id: 3659
Gene Symbol: IRF1
IRF1 		P10914 interferon regulatory factor 1 Transcription factor 230 0.468 0.769 0.99 0.310 limited 1.000 1 0 2018 2018
Entrez Id: 4916
Gene Symbol: NTRK3
NTRK3 		Q16288 neurotrophic receptor tyrosine kinase 3 Kinase 129 0.522 0.692 1.00 0.310 None 1.000 1 0 2017 2017
Entrez Id: 5885
Gene Symbol: RAD21
RAD21 		O60216 RAD21 cohesin complex component 52 0.528 0.846 1.00 0.310 None 1.000 1 0 2019 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1156 0.303 0.885 1.00 0.300 None 0.984 60 0 1999 2019
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1 		P26358 DNA methyltransferase 1 Epigenetic regulator 403 0.406 0.885 1.00 0.300 None 1.000 16 0 2004 2018
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 446 0.399 0.808 3.4E-05 0.300 None 1.000 15 4 2004 2020
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A 		Q9Y6K1 DNA methyltransferase 3 alpha 241 0.445 0.846 7.4E-39 0.280 None 1.000 8 0 2007 2019
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5 		P30532 cholinergic receptor nicotinic alpha 5 subunit Ion channel 56 0.593 0.577 2.1E-06 0.200 None 0.933 59 9 2008 2018
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2 		P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 283 0.420 0.846 7.1E-20 0.200 None 0.965 56 9 2001 2019