Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.600 None 1.000 10 2 2011 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 446 0.399 0.808 3.4E-05 0.420 None 1.000 2 0 2011 2019
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 517 0.373 0.962 1.00 0.410 None 1.000 1 0 1995 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.400 None 0.905 21 0 1994 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.400 None 0.950 20 0 1993 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.400 None 0.923 13 1 1993 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 942 0.328 0.923 6.0E-03 0.350 None 1.000 5 0 1995 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		P52701 mutS homolog 6 Nucleic acid binding 212 0.462 0.731 3.7E-05 0.340 None 1.000 4 1 2010 2020
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 457 0.378 0.885 8.0E-02 0.330 None 1.000 3 0 1993 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.320 None 1.000 2 0 2016 2018
Entrez Id: 5590
Gene Symbol: PRKCZ
PRKCZ 		Q05513 protein kinase C zeta Kinase 63 0.604 0.654 0.54 0.320 None 1.000 2 0 2017 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1156 0.303 0.885 1.00 0.320 None 1.000 2 0 2011 2018
Entrez Id: 5979
Gene Symbol: RET
RET 		P07949 ret proto-oncogene Kinase 453 0.392 0.885 1.00 0.320 None 1.000 2 0 2007 2019
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 404 0.406 0.808 0.90 0.310 None 1.000 1 0 2016 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.310 None 1.000 1 0 2017 2017
Entrez Id: 1630
Gene Symbol: DCC
DCC 		P43146 DCC netrin 1 receptor 175 0.471 0.808 0.99 0.310 None 1.000 1 0 2003 2003
Entrez Id: 581
Gene Symbol: BAX
BAX 		Q07812 BCL2 associated X, apoptosis regulator Signaling 338 0.417 0.885 0.32 0.310 None 1.000 1 0 2002 2002
Entrez Id: 4233
Gene Symbol: MET
MET 		P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 501 0.380 0.846 0.97 0.310 None 1.000 1 0 2018 2018
Entrez Id: 55294
Gene Symbol: FBXW7
FBXW7 		Q969H0 F-box and WD repeat domain containing 7 Enzyme modulator 237 0.465 0.808 1.00 0.310 None 1.000 1 0 2017 2017
Entrez Id: 5395
Gene Symbol: PMS2
PMS2 		P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 153 0.484 0.808 4.5E-27 0.310 None 1.000 1 1 2010 2010
Entrez Id: 6098
Gene Symbol: ROS1
ROS1 		P08922 ROS proto-oncogene 1, receptor tyrosine kinase Kinase 348 0.439 0.885 1.6E-72 0.310 None 1.000 1 0 2015 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2 		Q00987 MDM2 proto-oncogene Nucleic acid binding 669 0.362 0.846 1.00 0.310 None 1.000 1 0 1999 1999
Entrez Id: 7298
Gene Symbol: TYMS
TYMS 		P04818 thymidylate synthetase Enzyme 356 0.425 0.846 0.72 0.260 None 1.000 6 0 1998 2010
Entrez Id: 2778
Gene Symbol: GNAS
GNAS 		O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 300 0.420 0.885 0.68 0.110 None 1.000 1 0 2014 2019
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5 		Q13451 FKBP prolyl isomerase 5 Enzyme 157 0.524 0.769 0.73 0.110 None 1.000 1 0 2008 2019