Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 747 0.367 0.923 9.2E-29 0.100 None 0.979 47 0 1998 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 656 0.379 0.846 2.4E-25 0.100 None 0.968 31 0 1998 2019
Entrez Id: 5378
Gene Symbol: PMS1
PMS1 		P54277 PMS1 homolog 1, mismatch repair system component Nucleic acid binding 115 0.569 0.654 1.3E-17 0.400 None 1.000 20 0 1994 2017
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH 		Q9UIF7 mutY DNA glycosylase Enzyme 156 0.521 0.769 1.3E-18 0.100 None 1.000 17 0 2005 2019
Entrez Id: 27030
Gene Symbol: MLH3
MLH3 		Q9UHC1 mutL homolog 3 Nucleic acid binding 108 0.582 0.538 4.9E-08 0.700 moderate 0.933 15 0 2001 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 297 0.460 0.808 1.2E-24 0.330 limited 1.000 14 0 2003 2017
Entrez Id: 4437
Gene Symbol: MSH3
MSH3 		P20585 mutS homolog 3 Nucleic acid binding 245 0.474 0.769 7.4E-31 0.390 limited 0.857 14 0 1996 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 1213 0.320 0.923 7.9E-04 0.400 None 0.917 12 0 1996 2017
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2 		P37173 transforming growth factor beta receptor 2 Kinase 502 0.413 0.846 0.13 0.600 None 1.000 11 0 1995 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1368 0.303 0.885 1.00 0.100 None 1.000 11 0 1999 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 260 0.485 0.769 3.0E-19 0.340 limited 1.000 11 0 2013 2019
Entrez Id: 9156
Gene Symbol: EXO1
EXO1 		Q9UQ84 exonuclease 1 Enzyme 87 0.578 0.692 8.1E-13 0.350 disputed 0.778 9 0 2000 2016
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 684 0.374 0.885 5.6E-47 0.330 moderate 1.000 9 0 2005 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 1349 0.305 0.923 0.26 0.090 None 1.000 9 0 2002 2018
Entrez Id: 2191
Gene Symbol: FAP
FAP 		Q12884 fibroblast activation protein alpha Enzyme 216 0.496 0.808 1.9E-28 0.080 None 1.000 8 0 1999 2020
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 508 0.401 0.808 0.15 0.320 limited 1.000 8 0 1998 2016
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B 		P46527 cyclin dependent kinase inhibitor 1B 454 0.409 0.769 0.62 0.300 limited 1.000 8 0 1998 2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 1314 0.300 0.885 0.39 0.060 None 1.000 6 0 2004 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		P24385 cyclin D1 Enzyme modulator 859 0.344 0.923 0.89 0.050 None 0.400 5 0 2000 2017
Entrez Id: 60561
Gene Symbol: RINT1
RINT1 		Q6NUQ1 RAD50 interactor 1 19 0.743 0.231 5.3E-13 0.040 None 0.750 4 0 2014 2017
Entrez Id: 22909
Gene Symbol: FAN1
FAN1 		Q9Y2M0 FANCD2 and FANCI associated nuclease 1 93 0.610 0.577 1.7E-25 0.500 limited 1.000 4 0 2010 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1234 0.314 0.962 1.00 0.040 None 1.000 4 0 1999 2006
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		Q99728 BRCA1 associated RING domain 1 75 0.597 0.538 1.4E-24 0.300 limited 1.000 4 0 2001 2016
Entrez Id: 29126
Gene Symbol: CD274
CD274 		Q9NZQ7 CD274 molecule Receptor 1011 0.324 0.923 1.9E-02 0.030 None 1.000 3 0 2017 2019
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1 		P07099 epoxide hydrolase 1 196 0.500 0.846 3.2E-09 0.300 limited 1.000 3 0 1994 2015