Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 348
Gene Symbol: APOE
APOE 		P02649 apolipoprotein E 1049 0.338 0.962 1.9E-03 0.100 None 0.923 26 1 1996 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		P10636 microtubule associated protein tau 469 0.446 0.923 6.0E-03 0.030 None 1.000 3 1 2007 2019
Entrez Id: 351
Gene Symbol: APP
APP 		P05067 amyloid beta precursor protein Enzyme modulator 485 0.422 0.846 4.7E-02 0.020 None 1.000 2 0 2018 2018
Entrez Id: 4036
Gene Symbol: LRP2
LRP2 		P98164 LDL receptor related protein 2 254 0.491 0.846 1.00 0.020 None 1.000 2 3 2012 2017
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72 		Q96LT7 C9orf72-SMCR8 complex subunit 258 0.496 0.769 1.1E-06 0.020 None 1.000 2 0 2012 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		P23560 brain derived neurotrophic factor Signaling 992 0.345 0.923 0.66 0.020 None 0.500 2 2 2006 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		P00441 superoxide dismutase 1 Enzyme 689 0.379 0.962 0.18 0.020 None 0.500 2 0 2009 2013
Entrez Id: 1312
Gene Symbol: COMT
COMT 		P21964 catechol-O-methyltransferase Enzyme 622 0.400 0.923 1.1E-06 0.020 None 1.000 2 1 2014 2014
Entrez Id: 79068
Gene Symbol: FTO
FTO 		Q9C0B1 FTO alpha-ketoglutarate dependent dioxygenase 286 0.486 0.885 8.4E-08 0.020 None 1.000 2 0 2013 2017
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40 		O96008 translocase of outer mitochondrial membrane 40 Transporter 113 0.590 0.538 0.99 0.020 None 0.500 2 0 2011 2019
Entrez Id: 9197
Gene Symbol: SLC33A1
SLC33A1 		O00400 solute carrier family 33 member 1 Transporter 170 0.529 0.769 9.9E-05 0.010 None 1.000 1 0 2019 2019
Entrez Id: 4340
Gene Symbol: MOG
MOG 		Q16653 myelin oligodendrocyte glycoprotein Enzyme modulator 136 0.546 0.731 0.14 0.010 None 1.000 1 0 2019 2019
Entrez Id: 6683
Gene Symbol: SPAST
SPAST 		Q9UBP0 spastin Cellular structure 138 0.579 0.577 1.00 0.010 None 1.000 1 0 2000 2000
Entrez Id: 2896
Gene Symbol: GRN
GRN 		P28799 granulin precursor 412 0.435 0.846 7.0E-02 0.010 None 1.000 1 0 2014 2014
Entrez Id: 3977
Gene Symbol: LIFR
LIFR 		P42702 LIF receptor subunit alpha Signaling 198 0.523 0.808 1.5E-13 0.010 None 1.000 1 0 2018 2018
Entrez Id: 9365
Gene Symbol: KL
KL 		Q9UEF7 klotho Enzyme 332 0.448 0.769 2.2E-04 0.010 None < 0.001 1 0 2005 2005
Entrez Id: 3667
Gene Symbol: IRS1
IRS1 		P35568 insulin receptor substrate 1 233 0.488 0.769 2.4E-02 0.010 None 1.000 1 0 2019 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 985 0.337 0.885 3.2E-10 0.010 None 1.000 1 4 2011 2011
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 684 0.374 0.885 5.6E-47 0.010 None 1.000 1 0 2019 2019
Entrez Id: 4747
Gene Symbol: NEFL
NEFL 		P07196 neurofilament light 247 0.488 0.769 0.010 None 1.000 1 0 2019 2019
Entrez Id: 4878
Gene Symbol: NPPA
NPPA 		P01160 natriuretic peptide A 217 0.505 0.769 5.5E-04 0.010 None 1.000 1 0 2018 2018
Entrez Id: 5362
Gene Symbol: PLXNA2
PLXNA2 		O75051 plexin A2 307 0.447 0.808 1.1E-06 0.010 None 1.000 1 0 2018 2018
Entrez Id: 7486
Gene Symbol: WRN
WRN 		Q14191 WRN RecQ like helicase Enzyme 172 0.524 0.808 2.6E-34 0.010 None 1.000 1 0 2009 2009
Entrez Id: 6272
Gene Symbol: SORT1
SORT1 		Q99523 sortilin 1 Transporter 111 0.573 0.615 1.00 0.010 None 1.000 1 0 2013 2013
Entrez Id: 7421
Gene Symbol: VDR
VDR 		P11473 vitamin D receptor Nuclear receptor 852 0.352 0.885 1.7E-05 0.010 None 1.000 1 0 2012 2012