Source: CURATED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 232 0.236 0.962 0.53 0.700 None 0.984 6 84 1982 2020
Entrez Id: 4312
Gene Symbol: MMP1
MMP1 		P03956 matrix metallopeptidase 1 Enzyme 31 0.385 0.885 7.7E-18 0.600 None 1.000 1 0 1996 2014
Entrez Id: 4214
Gene Symbol: MAP3K1
MAP3K1 		Q13233 mitogen-activated protein kinase kinase kinase 1 Kinase 11 0.538 0.731 1.00 0.530 None 1.000 1 0 2007 2009
Entrez Id: 167465
Gene Symbol: ZNF366
ZNF366 		Q8N895 zinc finger protein 366 Transcription factor 15 0.729 0.423 7.0E-02 0.510 None 1.000 1 0 2010 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 83 0.328 0.923 6.0E-03 0.500 None 0.975 40 13 1987 2020
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 113 0.324 0.962 1.00 0.500 None 0.978 14 5 1988 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 57 0.367 0.923 9.2E-29 0.500 None 0.976 12 58 1976 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 98 0.292 0.923 1.00 0.500 None 0.978 8 34 2004 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 182 0.305 0.923 0.26 0.500 None 1.000 4 6 1998 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 47 0.460 0.808 1.2E-24 0.500 None 0.964 4 5 2002 2017
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		P21802 fibroblast growth factor receptor 2 Kinase 93 0.380 0.808 1.00 0.500 None 0.950 3 4 1991 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 56 0.379 0.846 2.4E-25 0.500 None 0.987 3 49 1995 2019
Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3 		P21860 erb-b2 receptor tyrosine kinase 3 Kinase 42 0.448 0.808 1.7E-15 0.500 None 1.000 2 3 1999 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 115 0.300 0.885 0.39 0.500 None 0.955 1 0 1995 2018
Entrez Id: 2475
Gene Symbol: MTOR
MTOR 		P42345 mechanistic target of rapamycin kinase Kinase 68 0.343 0.885 1.00 0.500 None 1.000 1 5 2003 2019
Entrez Id: 7015
Gene Symbol: TERT
TERT 		O14746 telomerase reverse transcriptase Enzyme 72 0.374 0.846 0.99 0.500 None 1.000 1 0 2002 2013
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 33 0.485 0.769 3.0E-19 0.500 None 1.000 1 5 2006 2020
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 72 0.374 0.885 5.6E-47 0.500 None 0.974 0 2 1996 2018
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 120 0.378 0.885 8.0E-02 0.450 None 1.000 4 7 1988 2016
Entrez Id: 5970
Gene Symbol: RELA
RELA 		Q04206 RELA proto-oncogene, NF-kB subunit Transcription factor 63 0.406 0.885 1.00 0.450 None 1.000 1 0 2002 2014
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		Q99728 BRCA1 associated RING domain 1 15 0.597 0.538 1.4E-24 0.450 None 1.000 0 1 2004 2008
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1 		Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 21 0.507 0.731 6.2E-17 0.450 None 1.000 0 1 2003 2008
Entrez Id: 9968
Gene Symbol: MED12
MED12 		Q93074 mediator complex subunit 12 Transcription factor 31 0.476 0.769 1.00 0.430 None 1.000 2 1 2014 2016
Entrez Id: 55294
Gene Symbol: FBXW7
FBXW7 		Q969H0 F-box and WD repeat domain containing 7 Enzyme modulator 23 0.465 0.808 1.00 0.420 None 0.667 1 4 2008 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		P24385 cyclin D1 Enzyme modulator 96 0.344 0.923 0.89 0.400 None 1.000 6 0 1992 2019