Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7471
Gene Symbol: WNT1
WNT1 		0.310 GeneticVariation disease BEFREE Our finding that homozygous and heterozygous variants in WNT1 predispose to low-bone-mass phenotypes might advance the development of more effective therapeutic strategies for congenital forms of bone fragility, as well as for common forms of age-related osteoporosis. 23499309 2013
Entrez Id: 5972
Gene Symbol: REN
REN 		0.310 AlteredExpression disease BEFREE The enhancement of renin and AGT expression in the bone tissue resulted in the increased production of angiotensin II which plays an important role in the pathology of age-related osteoporosis. 22785482 2012
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1 		0.310 Biomarker disease CTD_human Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals. 20723554 2010
Entrez Id: 5972
Gene Symbol: REN
REN 		0.310 Biomarker disease CTD_human Activation of renin-angiotensin system induces osteoporosis independently of hypertension. 18847324 2009
Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1 		0.310 GeneticVariation disease BEFREE In conclusion, differences in estrogen levels due to polymorphism at the aromatase CYP19 gene may predispose men to increased age-related bone loss and fracture risk. 15181061 2004
Entrez Id: 7471
Gene Symbol: WNT1
WNT1 		0.310 Biomarker disease CTD_human
Entrez Id: 23500
Gene Symbol: DAAM2
DAAM2 		0.300 Biomarker disease CTD_human An atlas of genetic influences on osteoporosis in humans and mice. 30598549 2019
Entrez Id: 5741
Gene Symbol: PTH
PTH 		0.300 Therapeutic disease CTD_human Combined treatment with vitamin K2 and PTH enhanced bone formation in ovariectomized rats and increased differentiation of osteoblast in vitro. 30639440 2019
Entrez Id: 10082
Gene Symbol: GPC6
GPC6 		0.300 Biomarker disease CTD_human Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. 28869591 2017
Entrez Id: 6320
Gene Symbol: CLEC11A
CLEC11A 		0.300 Biomarker disease CTD_human Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton. 27976999 2016
Entrez Id: 1591
Gene Symbol: CYP24A1
CYP24A1 		0.300 Biomarker disease CTD_human Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: effects of ketoconazole therapy. 22337913 2012
Entrez Id: 5741
Gene Symbol: PTH
PTH 		0.300 Therapeutic disease CTD_human Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives. 21306167 2011
Entrez Id: 5741
Gene Symbol: PTH
PTH 		0.300 Therapeutic disease CTD_human Normochromic normocytic anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormone. 19578808 2010
Entrez Id: 54503
Gene Symbol: ZDHHC13
ZDHHC13 		0.300 Biomarker disease CTD_human Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. 20548961 2010
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker disease CTD_human Cushing's disease in dogs and humans. 19153526 2009
Entrez Id: 2023
Gene Symbol: ENO1
ENO1 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 2244
Gene Symbol: FGB
FGB 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 3418
Gene Symbol: IDH2
IDH2 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 338382
Gene Symbol: RAB7B
RAB7B 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 10487
Gene Symbol: CAP1
CAP1 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 9948
Gene Symbol: WDR1
WDR1 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 5683
Gene Symbol: PSMA2
PSMA2 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 6251
Gene Symbol: RSU1
RSU1 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008
Entrez Id: 2934
Gene Symbol: GSN
GSN 		0.300 Biomarker disease CTD_human Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. 18924182 2008