×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
0.510
Biomarker
phenotype
CTD_human
Angiotensin-converting enzyme inhibition and angiotensin AT1 receptor blockade downregulate angiotensin-converting enzyme expression and attenuate renal injury in streptozotocin-induced diabetic rats.
23733546
2013
×
Entrez Id:
3630
Gene Symbol:
INS
INS
0.500
Biomarker
phenotype
CTD_human
Reversible impairment of renal function associated with enalapril in a diabetic patient.
9861226
1998
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
phenotype
CTD_human
Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus.
29988851
2018
×
Entrez Id:
406947
Gene Symbol:
MIR155
MIR155
0.300
Biomarker
phenotype
CTD_human
Urinary exosomal microRNAs in incipient diabetic nephropathy.
24223694
2013
×
Entrez Id:
406937
Gene Symbol:
MIR145
MIR145
0.300
Biomarker
phenotype
CTD_human
Urinary exosomal microRNAs in incipient diabetic nephropathy.
24223694
2013
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
phenotype
CTD_human
The Akt-FoxO3a-manganese superoxide dismutase pathway is involved in the regulation of oxidative stress in diabetic nephropathy.
23159718
2013
×
Entrez Id:
494336
Gene Symbol:
MIR424
MIR424
0.300
Biomarker
phenotype
CTD_human
Urinary exosomal microRNAs in incipient diabetic nephropathy.
24223694
2013
×
Entrez Id:
406919
Gene Symbol:
MIR130A
MIR130A
0.300
Biomarker
phenotype
CTD_human
Urinary exosomal microRNAs in incipient diabetic nephropathy.
24223694
2013
×
Entrez Id:
29108
Gene Symbol:
PYCARD
PYCARD
0.300
Biomarker
phenotype
CTD_human
Pathologically, hHcys-associated albuminuria , foot process effacement of podocytes, loss of podocyte slit diaphragm molecules, and glomerulosclerosis at the late stage were significantly improved by local ASC gene silencing or by caspase 1 inhibition.
22647887
2012
×
Entrez Id:
952
Gene Symbol:
CD38
CD38
0.300
Biomarker
phenotype
CTD_human
This enhanced glomerular injury in CD38 (-/-) or CD38 -shRNA mice was accompanied by increased albuminuria and proteinuria.
21992601
2012
×
Entrez Id:
834
Gene Symbol:
CASP1
CASP1
0.300
Biomarker
phenotype
CTD_human
Pathologically, hHcys-associated albuminuria , foot process effacement of podocytes, loss of podocyte slit diaphragm molecules, and glomerulosclerosis at the late stage were significantly improved by local ASC gene silencing or by caspase 1 inhibition.
22647887
2012
×
Entrez Id:
183
Gene Symbol:
AGT
AGT
0.300
Biomarker
phenotype
CTD_human
Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats.
21896938
2011
×
Entrez Id:
1356
Gene Symbol:
CP
CP
0.300
Biomarker
phenotype
CTD_human
Multivariate regression analysis demonstrated that elevated serum ceruloplasmin was a determinant of albuminuria independently of conventional risk factors.
21752484
2011
×
Entrez Id:
2262
Gene Symbol:
GPC5
GPC5
0.300
Therapeutic
phenotype
CTD_human
Common variation in GPC5 is associated with acquired nephrotic syndrome.
21441931
2011
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
phenotype
CTD_human
Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling.
20175764
2010
×
Entrez Id:
4690
Gene Symbol:
NCK1
NCK1
0.300
Biomarker
phenotype
CTD_human
Nck proteins maintain the adult glomerular filtration barrier.
19443634
2009
×
Entrez Id:
8440
Gene Symbol:
NCK2
NCK2
0.300
Biomarker
phenotype
CTD_human
Nck proteins maintain the adult glomerular filtration barrier.
19443634
2009
×
Entrez Id:
183
Gene Symbol:
AGT
AGT
0.300
Biomarker
phenotype
CTD_human
A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.
18679781
2008
×
Entrez Id:
5972
Gene Symbol:
REN
REN
0.300
Biomarker
phenotype
CTD_human
A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.
18679781
2008
×
Entrez Id:
85480
Gene Symbol:
TSLP
TSLP
0.300
Biomarker
phenotype
CTD_human
All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice.
17686814
2007
×
Entrez Id:
6648
Gene Symbol:
SOD2
SOD2
0.300
Biomarker
phenotype
CTD_human
Genetic factors in diabetic nephropathy.
17942768
2007
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
0.300
Biomarker
phenotype
CTD_human
In summary, in transgenic mice with podocyte COX-2 overexpression, PAN increased albuminuria and induced foot process fusion.
17890881
2007
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.300
Biomarker
phenotype
CTD_human
Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration.
17167242
2006
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.300
Biomarker
phenotype
CTD_human
Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration.
17167242
2006
×
Entrez Id:
7827
Gene Symbol:
NPHS2
NPHS2
0.300
Biomarker
phenotype
CTD_human
However, the first change induced by PA was the change of podocin localization from a linear pattern to a dot-like one prior to the onset of albuminuria .
15684566
2005