Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.510 Biomarker phenotype CTD_human Angiotensin-converting enzyme inhibition and angiotensin AT1 receptor blockade downregulate angiotensin-converting enzyme expression and attenuate renal injury in streptozotocin-induced diabetic rats. 23733546 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.510 Therapeutic phenotype RGD Beneficial effect of TGFbeta antagonism in treating diabetic nephropathy depends on when treatment is started. 16902320 2006
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.510 GeneticVariation phenotype LHGDN Alpha-adducin and angiotensin-converting enzyme polymorphisms in hypertension: evidence for a joint influence on albuminuria. 16612256 2006
Entrez Id: 3630
Gene Symbol: INS
INS 		0.500 Biomarker phenotype CTD_mouse Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice. 29420703 2018
Entrez Id: 3630
Gene Symbol: INS
INS 		0.500 Biomarker phenotype CTD_human Reversible impairment of renal function associated with enalapril in a diabetic patient. 9861226 1998
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker phenotype CTD_human Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus. 29988851 2018
Entrez Id: 406947
Gene Symbol: MIR155
MIR155 		0.300 Biomarker phenotype CTD_human Urinary exosomal microRNAs in incipient diabetic nephropathy. 24223694 2013
Entrez Id: 406937
Gene Symbol: MIR145
MIR145 		0.300 Biomarker phenotype CTD_human Urinary exosomal microRNAs in incipient diabetic nephropathy. 24223694 2013
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker phenotype CTD_human The Akt-FoxO3a-manganese superoxide dismutase pathway is involved in the regulation of oxidative stress in diabetic nephropathy. 23159718 2013
Entrez Id: 494336
Gene Symbol: MIR424
MIR424 		0.300 Biomarker phenotype CTD_human Urinary exosomal microRNAs in incipient diabetic nephropathy. 24223694 2013
Entrez Id: 406919
Gene Symbol: MIR130A
MIR130A 		0.300 Biomarker phenotype CTD_human Urinary exosomal microRNAs in incipient diabetic nephropathy. 24223694 2013
Entrez Id: 29108
Gene Symbol: PYCARD
PYCARD 		0.300 Biomarker phenotype CTD_human Pathologically, hHcys-associated albuminuria, foot process effacement of podocytes, loss of podocyte slit diaphragm molecules, and glomerulosclerosis at the late stage were significantly improved by local ASC gene silencing or by caspase 1 inhibition. 22647887 2012
Entrez Id: 952
Gene Symbol: CD38
CD38 		0.300 Biomarker phenotype CTD_human This enhanced glomerular injury in CD38(-/-) or CD38-shRNA mice was accompanied by increased albuminuria and proteinuria. 21992601 2012
Entrez Id: 834
Gene Symbol: CASP1
CASP1 		0.300 Biomarker phenotype CTD_human Pathologically, hHcys-associated albuminuria, foot process effacement of podocytes, loss of podocyte slit diaphragm molecules, and glomerulosclerosis at the late stage were significantly improved by local ASC gene silencing or by caspase 1 inhibition. 22647887 2012
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.300 Biomarker phenotype CTD_human Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats. 21896938 2011
Entrez Id: 1356
Gene Symbol: CP
CP 		0.300 Biomarker phenotype CTD_human Multivariate regression analysis demonstrated that elevated serum ceruloplasmin was a determinant of albuminuria independently of conventional risk factors. 21752484 2011
Entrez Id: 2262
Gene Symbol: GPC5
GPC5 		0.300 Therapeutic phenotype CTD_human Common variation in GPC5 is associated with acquired nephrotic syndrome. 21441931 2011
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker phenotype CTD_human Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling. 20175764 2010
Entrez Id: 4690
Gene Symbol: NCK1
NCK1 		0.300 Biomarker phenotype CTD_human Nck proteins maintain the adult glomerular filtration barrier. 19443634 2009
Entrez Id: 8440
Gene Symbol: NCK2
NCK2 		0.300 Biomarker phenotype CTD_human Nck proteins maintain the adult glomerular filtration barrier. 19443634 2009
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.300 Biomarker phenotype CTD_human A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. 18679781 2008
Entrez Id: 5972
Gene Symbol: REN
REN 		0.300 Biomarker phenotype CTD_human A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. 18679781 2008
Entrez Id: 85480
Gene Symbol: TSLP
TSLP 		0.300 Biomarker phenotype CTD_human All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice. 17686814 2007
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.300 Biomarker phenotype CTD_human Genetic factors in diabetic nephropathy. 17942768 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.300 Biomarker phenotype CTD_human In summary, in transgenic mice with podocyte COX-2 overexpression, PAN increased albuminuria and induced foot process fusion. 17890881 2007