×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
We found dramatic and consistent loss of immunocytochemical staining for LR11 in histologically normal-appearing neurons in AD brains.
15313836
2004
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
AlteredExpression
disease
LHGDN
We found dramatic and consistent loss of immunocytochemical staining for LR11 in histologically normal-appearing neurons in AD brains.
15313836
2004
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
AlteredExpression
disease
LHGDN
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
16174740
2005
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
LHGDN
Newly published results indicate that the sorting protein-related receptor sorLA /LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease .
16565469
2006
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
We hypothesize that LR11 loss may be specific to sporadic AD and influence amyloid pathology through mechanisms independent of substrate-enzyme interactions regulated by FAD mutations.
16957580
2006
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
AlteredExpression
disease
BEFREE
These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease .
17220890
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
LHGDN
These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease .
17220890
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
Several individual SNPs and SNP haplotypes were significantly associated with AD in this prospectively collected community-based cohort, confirming the previously reported positive association of SORL1 with AD .
17420311
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
AlteredExpression
disease
LHGDN
LR11 levels in MCI were intermediate between no cognitive impairment and AD .
17721864
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
BEFREE
Association between genetic variants in sortilin-related receptor 1 (SORL1 ) and Alzheimer's disease in adults with Down syndrome.
17826910
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
SORL1 plays a role in amyloid precursor protein processing and has been associated with the risk of AD .
17903297
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
BEFREE
Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1 ) gene were shown to be significantly associated with AD in several cohorts.
17975299
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
LHGDN
Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease .
17978276
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
BEFREE
However, our study suggests that certain SORL1 haplotypes at SNPs 19-24 modulated risk of AD in our Chinese population.
18063222
2009
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
LHGDN
These results provide an independent replication of the association between AD and SORL1 .
18090307
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
These results provide an independent replication of the association between AD and SORL1 .
18090307
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
LHGDN
Alzheimer's disease: advances in trafficking.
18093545
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
In vivo elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor.
18160637
2007
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
BEFREE
Recently, variants in the sortilin-related receptor 1 gene, SORL1 , were associated with Alzheimer disease .
18322368
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
LHGDN
SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.
18407551
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
BEFREE
Thus our data suggest that SORL1 gene variants might influence AD pathology.
18541377
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
BEFREE
Indeed, there have been reports of associations between variation in SORL1 and AD risk.
18562096
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
LHGDN
Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD .
18685254
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
Biomarker
disease
BEFREE
Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD .
18685254
2008
×
Entrez Id:
6653
Gene Symbol:
SORL1
SORL1
0.500
GeneticVariation
disease
LHGDN
The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.
18713574
2008