Gene: SORL1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE We found dramatic and consistent loss of immunocytochemical staining for LR11 in histologically normal-appearing neurons in AD brains. 15313836 2004
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 AlteredExpression disease LHGDN We found dramatic and consistent loss of immunocytochemical staining for LR11 in histologically normal-appearing neurons in AD brains. 15313836 2004
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 AlteredExpression disease LHGDN Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. 16174740 2005
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease LHGDN Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease. 16565469 2006
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE We hypothesize that LR11 loss may be specific to sporadic AD and influence amyloid pathology through mechanisms independent of substrate-enzyme interactions regulated by FAD mutations. 16957580 2006
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease BEFREE Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome. 17826910 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 AlteredExpression disease BEFREE These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease. 17220890 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE Several individual SNPs and SNP haplotypes were significantly associated with AD in this prospectively collected community-based cohort, confirming the previously reported positive association of SORL1 with AD. 17420311 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease LHGDN These results provide an independent replication of the association between AD and SORL1. 18090307 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease LHGDN These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease. 17220890 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 AlteredExpression disease LHGDN LR11 levels in MCI were intermediate between no cognitive impairment and AD. 17721864 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE In vivo elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor. 18160637 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE These results provide an independent replication of the association between AD and SORL1. 18090307 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE SORL1 plays a role in amyloid precursor protein processing and has been associated with the risk of AD. 17903297 2007
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE Here, we show that LR11 deficiency in this AD mouse model significantly increases Abeta levels and exacerbates early amyloid pathology in brain, causing a forward shift in disease onset that is LR11 gene dose-dependent. 19036982 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease BEFREE Thus our data suggest that SORL1 gene variants might influence AD pathology. 18541377 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease BEFREE Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. 17975299 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease LHGDN Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD. 18685254 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease LHGDN Alzheimer's disease: advances in trafficking. 18093545 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease LHGDN The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease. 18713574 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 Biomarker disease BEFREE Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD. 18685254 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease LHGDN Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease. 17978276 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease LHGDN SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. 18407551 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease BEFREE Indeed, there have been reports of associations between variation in SORL1 and AD risk. 18562096 2008
Entrez Id: 6653
Gene Symbol: SORL1
SORL1 		0.500 GeneticVariation disease BEFREE Recently, variants in the sortilin-related receptor 1 gene, SORL1, were associated with Alzheimer disease. 18322368 2008