These results are the first to identify that platelet-inflammasome dependent shedding of IL-1β carrying platelet EVs promote lung vaso-occlusion in SCD.
SNPs these proteins were associated with the constructive activation of the Inflammasome and excessive production of IL-1β induce a serious autoinflammatory disease, as sickle cell anemia (SCA).
Peripheral blood monocytes from patients with sickle cell disease had 34% more IL-1beta (P =.002) and 139% more TNF-alpha (P =.002) per cell than normal monocytes.