Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26103
Gene Symbol: LRIT1
LRIT1
0.010 Biomarker disease BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
Entrez Id: 3550
Gene Symbol: IK
IK
0.010 GeneticVariation disease BEFREE </p> Results:In general, nutrition is experienced, not only by athletes themselves but also by technicians and coaches, as a tool for improving performance and as such assimilated to an aspect of training but in the presence of factors of vulnerability towards the ED by of the young athletes the exaggerated tendency to manipulate the weight can determine the appearance of an eating disorder or of the so-called athletic anorexia or the RED-S. </p> Conclusions:It is important to emphasize that not only do professional athletes suffer from it, but also good-looking amateurs and amateurs. 31684854 2020
Entrez Id: 79801
Gene Symbol: SHCBP1
SHCBP1
0.010 Biomarker disease BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
Entrez Id: 8444
Gene Symbol: DYRK3
DYRK3
0.010 GeneticVariation disease BEFREE </p> Results:In general, nutrition is experienced, not only by athletes themselves but also by technicians and coaches, as a tool for improving performance and as such assimilated to an aspect of training but in the presence of factors of vulnerability towards the ED by of the young athletes the exaggerated tendency to manipulate the weight can determine the appearance of an eating disorder or of the so-called athletic anorexia or the RED-S. </p> Conclusions:It is important to emphasize that not only do professional athletes suffer from it, but also good-looking amateurs and amateurs. 31684854 2020
Entrez Id: 5066
Gene Symbol: PAM
PAM
0.010 Biomarker disease BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.010 Biomarker disease BEFREE AKT regulates the IKK/NF-κB signaling pathway; therefore, this study aimed to investigate the role of PRIP/AKT signaling in LPS-mediated neuroinflammation-induced anorexia. 31589911 2019
Entrez Id: 10022
Gene Symbol: INSL5
INSL5
0.010 Biomarker disease BEFREE Insulin-like peptide 5 (INSL5) is a very important pharma target for treating human conditions such as anorexia and diabetes. 31780677 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.010 Biomarker disease BEFREE The present study examined whether HIF-1 was involved in the oxidative stress and anorectic action of AMPH. 31295466 2019
Entrez Id: 551
Gene Symbol: AVP
AVP
0.010 Biomarker disease BEFREE Copeptin also inversely correlated with the quality of life domains in CF patients: vitality and eating habits, mostly loss of appetite (<i>p</i> = 0.031 and <i>p</i> = 0.016, respectively). 31736654 2019
Entrez Id: 146059
Gene Symbol: CDAN1
CDAN1
0.010 Biomarker disease BEFREE One DLT (anorexia and stomatitis, respectively) occurred with each of regimens 2 and 3. 29995287 2019
Entrez Id: 23054
Gene Symbol: NCOA6
NCOA6
0.010 Biomarker disease BEFREE PRIP gene (Prip1 and Prip2) knockout (Prip-KO) mice intraperitoneally (ip) administered with LPS exhibited increased anorexia responses compared with wild-type (WT) controls. 31589911 2019
Entrez Id: 5334
Gene Symbol: PLCL1
PLCL1
0.010 Biomarker disease BEFREE PRIP gene (Prip1 and Prip2) knockout (Prip-KO) mice intraperitoneally (ip) administered with LPS exhibited increased anorexia responses compared with wild-type (WT) controls. 31589911 2019
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.010 AlteredExpression disease BEFREE One subpopulation co-expresses the long form of the leptin receptor (LepRb) and is activated by the anorectic hormone leptin (Nts<sup>LepRb</sup> neurons). 30755658 2019
Entrez Id: 133
Gene Symbol: ADM
ADM
0.010 Biomarker disease BEFREE Here, we investigated if peripheral co-administration of ADM and glucagon-like peptide 1 (GLP-1) could subdue the hypoglycaemic effects of ADM while enhancing its anorectic properties. 30396073 2019
Entrez Id: 407011
Gene Symbol: MIR23B
MIR23B
0.010 AlteredExpression disease BEFREE Moreover, patients with anorexia showed higher levels of miR-23b in plasma than those without anorexia. 31176730 2019
Entrez Id: 6524
Gene Symbol: SLC5A2
SLC5A2
0.010 Biomarker disease BEFREE The real-world efficacy and safety profile of SGLT2 inhibitors in Chinese patients was comparable to that reported in Phase III clinical trials, with the exception of appetite loss among patients who received canagliflozin. 30402655 2019
Entrez Id: 10725
Gene Symbol: NFAT5
NFAT5
0.010 Biomarker disease BEFREE TonEBP (+/-) mice show reduced sickness responses, which include anorexia and hyperthermia, that are initially induced by tumor necrosis factor (TNF)-α. TonEBP (+/-) mice also show lower levels of TNF-α-induced hypothalamic expression of POMC and pro-inflammatory cytokines. 31281956 2019
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.010 Biomarker disease BEFREE Using a validated novel IL-6-reporter mouse strain, we investigated the interactions in PBNel between GLP-1, IL-6, and calcitonin gene-related peptide (CGRP, a well-known mediator of anorexia). 30889580 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.010 Biomarker disease BEFREE The present study examined whether HIF-1 was involved in the oxidative stress and anorectic action of AMPH. 31295466 2019
Entrez Id: 2056
Gene Symbol: EPO
EPO
0.010 Biomarker disease BEFREE In the multivariate analysis of all the examined parameters in Cox models, independent unfavorable prognostic factors were increased ploidy score, existence of bone metastases, use of epoetin, and existence of side-effects such as anorexia, mucositis, and weight loss. 30587631 2019
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.010 Biomarker disease BEFREE PRIP gene (Prip1 and Prip2) knockout (Prip-KO) mice intraperitoneally (ip) administered with LPS exhibited increased anorexia responses compared with wild-type (WT) controls. 31589911 2019
Entrez Id: 4879
Gene Symbol: NPPB
NPPB
0.010 Biomarker disease BEFREE BNP or Pro-BNP was inversely associated with overall survival (hazard ratio = 2.27; 95% CI, 1.29-3.97) in univariate Cox regression analysis, and remained significant in multivariate Cox regression analysis (hazard ratio = 3.09; 95% CI, 1.40-6.84) after adjusting for treatment group and known prognostic variables such as performance status, albumin, creatinine, delirium, dyspnea, and anorexia. 31128228 2019
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
0.010 Biomarker disease BEFREE We hypothesized that the hypothalamic mechanistic target of rapamycin (mTOR) pathway, a well-established nutrient sensor and modulator of appetite and puberty, could also mediate the anorectic effect of E2. 29914932 2018
Entrez Id: 3572
Gene Symbol: IL6ST
IL6ST
0.010 AlteredExpression disease BEFREE Brewer's yeast administration dose-dependently induced fever, lethargy, anorexia and body mass stunting that was accompanied by increased blood plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α and activation of inflammatory transcription factors (nuclear factor (NF) for interleukin-6, signal transducer and activator of transcription (STAT)-3, and NF-κB)) in the hypothalamus and circumventricular organs. 29074357 2018
Entrez Id: 7432
Gene Symbol: VIP
VIP
0.010 Biomarker disease BEFREE Vasoactive intestinal peptide (VIP) is a neurotransmitter with anorectic effect that acts in the hypothalamus to regulate food intake. 28752412 2018