Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.500 Biomarker disease CTD_human Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury. 12160931 2002
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.500 Biomarker disease RGD Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase. 12051993 2002
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1 		0.320 Biomarker disease CTD_human Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. 17563610 2007
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1 		0.320 GeneticVariation disease BEFREE An important finding of this study is that GSTT1 gene deletion might have a protective effect on the development of asbestosis. 17563610 2007
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1 		0.320 GeneticVariation disease BEFREE The GSTM1 deletion remained associated with the presence of x-ray evidence of asbestosis after adjustment for GSTT1 genotype. 9055949 1997
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.310 Biomarker disease CTD_human Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos. 12368052 2002
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.310 GeneticVariation disease LHGDN Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos. 12368052 2002
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.310 GeneticVariation disease BEFREE Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos. 12368052 2002
Entrez Id: 383
Gene Symbol: ARG1
ARG1 		0.300 Biomarker disease CTD_human Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis. 26699812 2016
Entrez Id: 22926
Gene Symbol: ATF6
ATF6 		0.300 Biomarker disease CTD_human Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages. 25324550 2014
Entrez Id: 1649
Gene Symbol: DDIT3
DDIT3 		0.300 Biomarker disease CTD_human Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages. 25324550 2014
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5 		0.300 Biomarker disease CTD_human Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages. 25324550 2014
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3 		0.300 Biomarker disease CTD_human Genes involved in innate immunity associated with asbestos-related fibrotic changes. 24142982 2014
Entrez Id: 7171
Gene Symbol: TPM4
TPM4 		0.300 Biomarker disease CTD_human Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. 22537621 2012
Entrez Id: 7001
Gene Symbol: PRDX2
PRDX2 		0.300 Biomarker disease CTD_human Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. 22537621 2012
Entrez Id: 1675
Gene Symbol: CFD
CFD 		0.300 Biomarker disease CTD_human Adipokine adipsin is associated with the degree of lung fibrosis in asbestos-exposed workers. 22832039 2012
Entrez Id: 5052
Gene Symbol: PRDX1
PRDX1 		0.300 Biomarker disease CTD_human Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure. 22537621 2012
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		0.300 Biomarker disease CTD_human Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis. 21514415 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker disease CTD_human Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases. 20486865 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		0.300 Biomarker disease CTD_human Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. 16221779 2005
Entrez Id: 147719
Gene Symbol: LYPD4
LYPD4 		0.020 Biomarker disease BEFREE Considering asbestos related diseases (ARDs), statistically significant excesses were observed for MN of peritoneum (SMR: men 14.19; women 15.14), pleura (SMR: 22.35 and 48.10), lung (SMR: 1.67 and 1.67), ovary (in the highest exposure class SMR 2.45), and asbestosis (SMR: 507 and 1023). 31391078 2019
Entrez Id: 147719
Gene Symbol: LYPD4
LYPD4 		0.020 Biomarker disease BEFREE Mortality was significantly increased for all deaths (SMR: men: 1.05, 95% CI 1.03 to 1.06; women: 1.17, 95% CI to 1.12 to 1.22), all malignancies combined (SMR: men: 1.17, 95% CI to 1.14 to 1.20; women: 1.33, 95% CI 1.24 to 1.43), pleural and peritoneal malignancies (SMR: men: 13.28 and 4.77, 95% CI 12.24 to 14.37 and 4.00 to 5.64; women: 28.44 and 6.75, 95% CI 23.83 to 33.69 and 4.70 to 9.39), lung (SMR: men: 1.26, 95% CI 1.21 to 1.31; women: 1.43, 95% CI 1.13 to 1.78) and ovarian cancer (SMR=1.38, 95% CI 1.00 to 1.87) and asbestosis (SMR: men: 300.7, 95% CI 270.7 to 333.2; women: 389.6, 95% CI 290.1 to 512.3). 28775133 2017
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.020 GeneticVariation disease BEFREE The associations between MnSOD Ala -9Val polymorphism and the risk of asbestosis and between iNOS genotypes and asbestosis were modified by CAT -262 C > T polymorphism (P = 0.038; P = 0.031). 23984360 2013
Entrez Id: 6648
Gene Symbol: SOD2
SOD2 		0.020 GeneticVariation disease BEFREE Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer. 18420450 2008
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1 		0.020 GeneticVariation disease BEFREE The risk of GSTM1-null and GSTT1-null genotype for asbestosis did not change after adjustment by cumulative exposure, smoking, gender, and age. 17563610 2007