|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus the HLA-DRB1 and B3 genes present in patients with autoimmune disease appear to be the same as those present in the general population.
|
1617108 |
1992 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
In pemphigus vulgaris, a dermatological autoimmune disease, specific human leukocyte antigen (HLA) class II alleles, DR4 (DRB1*0402) and DRw14 (DRB1*1401, in linkage disequilibrium with DQB1*0503), are thought to be susceptibility genes involved in the onset of the disease.
|
7747528 |
1995 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The HLA DRB1*08032 allele was strongly associated with susceptibility to methimazole-induced agranulocytosis, suggesting that cellular autoimmunity may be involved in its development.
|
8602707 |
1996 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the development of HLA-DR-associated autoimmune diseases, we generated transgenic (Tg) mice with HLA-DRA-IE alpha and HLA-DRB1*0401-IE beta chimeric genes.
|
8676084 |
1996 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data indicated that there was a generalized genetic factor within or associated with the DRB1*0301/DQA1*0501/DQB1*0201 haplotype, and a more restricted effect with the DRB1*0405/DQA1*0301/DQB1*0401 haplotype which led to thyroid autoimmunity in patients with insulin-dependent diabetes mellitus.
|
8977762 |
1996 |
|
HLA-DRB1
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Rheumatoid arthritis (RA) is an autoimmune disease that is strongly associated with the expression of several HLA-DR haplotypes, including DR1 (DRB1*0101).
|
9091584 |
1997 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Patients with schizophrenia rarely develop rheumatoid arthritis, an autoimmune disease that exhibits genetic association with the HLA DRB1*04 gene.
|
9713901 |
1998 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
NCA-LEMS was strongly associated with DRB1*0301 (p<0.0001) and DQB1*0201 (p<0.0001), suggesting that NCA-LEMS is an autoimmune disorder associated with the DR3-DQ2 extended haplotype.
|
10980394 |
2000 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Since the DRB1*0301 allele is part of the extended ancestral 8.1 haplotype, it carries with it additional risk factors for autoimmunity, including TNFA*2 and C4A*Q0.
|
10807521 |
2000 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although HLA-DRB1 and -DQA1 alleles have been associated with adult and juvenile idiopathic inflammatory myopathies (JIIM), they only partially account for the genetic risk for these autoimmune disorders.
|
10886238 |
2000 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The protection may be explained by the presentation of DRB1-derived peptides by DQ to immunoregulatory T cells, because it was demonstrated in various autoimmune disease models that T cell responses to certain self-Ags can be involved in disease suppression.
|
11290778 |
2001 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Although hepatitis B vaccination given during the neonatal period does not increase autoantibody production in 6-year-old immunized children, we deem useful a more prolonged follow-up for these nonresponder children carrying certain HLA haplotypes (such as C4AQ0,DRB1*0301,DQB1*02), particularly because most autoimmune diseases do not develop until later in life.
|
12093985 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Particularly, the association in all Caucasian populations of an impressive number of autoimmune diseases with genes from the HLA-B8,DR3 haplotype that is part of the ancestral haplotype (AH) 8.1 HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201 has been reported by different research groups.
|
12849055 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results show that there are common risk and protection alleles in both loci, suggesting a core of genetic association with autoimmunity (HLA-DRB1*0301 risk; A9 protection) that could be modulated by other alleles/loci or environmental factors toward one or another disease.
|
14679082 |
2003 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Associations between the DRB1*04 alleles and prediabetic islet autoimmunity were generally in the same direction as those with diabetes.
|
14679080 |
2003 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The results demonstrate that progression to autoimmunity as measured by the appearance of autoantibodies is strongly associated with the class 2 alleles DRB1*03 and DRB*04 and with DRB1*03/04 heterozygosity.
|
12694582 |
2003 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We hypothesized that nonislet autoimmunity might be expressed in a similar manner in Korean as well as in Caucasian patients and correlated with the DRB1-DQB1 haplotypes.
|
15699495 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The INS and the DRB1 loci appear to contribute to the pathogenesis of type 1 diabetes by initiating/modifying insulin-specific autoimmunity.
|
16025255 |
2005 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma.
|
16005081 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found no evidence for association of these variants with T1D overall, nor in subgroups of patients with or without the major risk genotypes at HLA-DRB1, at insulin (INS), or positive or negative for autoantibodies specific to other autoimmune diseases.
|
16198136 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
|
16385499 |
2006 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
In family A, all MS patients and two of five individuals with MS immunopathic trait had HLA DRB1*(15) and in family B, all blood relatives had the rare HLA type DRB1*0103, which is associated with other autoimmune diseases.
|
17262999 |
2006 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The following significant findings were observed: 1) a significant excess of autoimmunity in first-degree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1*0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01).
|
16502215 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases and 426 controls.
|
17182961 |
2006 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
LHGDN |
The strong association between CP and HLA-DRB1*03, an allele linked to a wide range of autoimmune conditions, further supports the view that CP may represent a clinical manifestation of an autoimmune disease.
|
16463424 |
2006 |