|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The strong association between CP and HLA-DRB1*03, an allele linked to a wide range of autoimmune conditions, further supports the view that CP may represent a clinical manifestation of an autoimmune disease.
|
16463424 |
2006 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
It is noteworthy that certain genes and haplotypes, notably HLA-DRB1*0301, DQA1*0501, DQB1*0201 in Caucasians and DRB1*0405, DQA1*03, DQB1*0401 in Asians, as well as PTPN22, seem to be associated with a variety of autoimmune diseases.
|
16890892 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Preliminary results showed increased frequencies of DRB1*11- and DRB*16-associated haplotypes that were found to be protective for autoimmune diseases in some populations.
|
17445222 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The development of MS is influenced by environmental factors, particularly the Epstein-Barr virus (EBV), and genetic factors, which include specific HLA types, particularly DRB1*1501-DQA1*0102-DQB1*0602, and a predisposition to autoimmunity in general.
|
17547851 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
LHGDN |
DRB3*0101 and DRB1*0301 belong to an ancestral haplotype and are associated with many autoimmune diseases linked to antigen presentation, but whereas DR3 is susceptible to type 1 diabetes DR52a is not.
|
17583734 |
2007 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared with those with low GADA titers, patients with high GADA titers had more prominent traits of insulin deficiency and a profile of more severe autoimmunity resulting in higher A1C, lower BMI, a lower prevalence of metabolic syndrome and its components (P < 0.02 for all), a higher prevalence of IA-2As, TPO antibodies (P < 0.003 for both), and DRB1*03-DQB1*0201 (50 vs. 26.8%, P = 0.001), and a decreasing frequency of DQB1*0602 and DRB1*0403 (from type 2 to low and to high GADA titer autoimmune diabetes; P < 0.001 for trend for both comparisons).
|
17392553 |
2007 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity.
|
17728790 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus.
|
17936227 |
2007 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
PTPN22 appears to be primarily associated with anticitrulline autoimmunity, whereas HLA-DRB1 SE is independently associated with RF.
|
19714585 |
2009 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Rheumatoid arthritis (RA) is an autoimmune disease that affects mostly women and is associated with HLA-DRB1 genes having in common a shared epitope sequence.
|
19117368 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Rheumatoid arthritis (RA) is an autoimmune disease that affects mostly women and is associated with HLA-DRB1 genes having in common a shared epitope sequence.
|
19117368 |
2009 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study points to a gene-dose-dependent, protective role for LILRA3, the deletion of which synergizes with HLA-DRB1(*)1501 to increase the risk of R-MS. We also investigated whether the risk of suffering R-MS might be influenced by the genotypic diversity of killer-cell Ig-like receptors (KIRs), located only approximately 400 kb telomeric to LILRA3, and implicated in autoimmunity and defence against viruses.
|
19421224 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.
|
19675171 |
2009 |
|
HLA-DRB1
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest that the interaction between VDR and HLA alleles is mediated by VDRE present in the promoter region of HLA-DRB1 0301 allele, which may be detrimental for the manifestation of T1D in the absence of 1,25-(OH)(2)D(3) in early childhood due to poor expression of DRB1 0301 in the thymus resulting in autoimmunity.
|
19956544 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens.
|
18954286 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The monomodular-short haplotype with a single C4B gene and the absence of C4A, which is in linkage-disequilibrium with HLA DRB1*0301 in Europeans and a strong risk factor for autoimmune diseases, has a frequency of 0.012 in AIA but 0.106 among healthy European Americans (p=6.6x10(-8)).
|
19135723 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Besides the acknowledged correlation between the HLA-A*02 and HLA-B*15 alleles (as well as low birth weight) and type I diabetes and between the HLA-B*38 and HLA-DRB1*13 alleles (as well as high birth weight) and several autoimmune diseases, we cannot predict if our babies, healthy at birth, will suffer from these pathologies during life.
|
19500315 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease.
|
20629510 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Antibodies to citrullinated proteins are associated with HLA 'shared epitope' alleles, and autoimmunity to at least one antigenic sequence, the CEP-1 peptide from citrullinated alpha-enolase (KIHAcitEIFDScitGNPTVE), shows a specific association with HLA-DRB1*0401, *0404, 620W PTPN22, and smoking.
|
20192991 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Multiple autoimmune disorders (e.g.Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease.
|
20631027 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In our population, over 50% of AG patients carry the HLA-DRB1*03 or *04 alleles associated with autoimmune diseases, suggesting that this subset of AG patients has a genetic predisposition to autoimmunity.
|
20627832 |
2010 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
In Caucasians, we highlighted the definite protective role of HLA-DRB1*14 and DRB1*07 for MS. DRB1*03 is probably the only risk factor for MS besides DRB1*15 and a common genetic foundation for autoimmune disease.
|
21440682 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.
|
20797713 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, the DRB1*0901 haplotype and the risk alleles of ERBB3, CLEC16A and CTLA4 were positively associated with the co-occurrence of thyroid autoimmunity.
|
22069271 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of HLA-DRB1 or HLA-DQB1 are related to production of AAs in autoimmune diseases.
|
21557256 |
2011 |