|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases and 426 controls.
|
17182961 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Rheumatoid arthritis (RA) is an autoimmune disease that affects mostly women and is associated with HLA-DRB1 genes having in common a shared epitope sequence.
|
19117368 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In our population, over 50% of AG patients carry the HLA-DRB1*03 or *04 alleles associated with autoimmune diseases, suggesting that this subset of AG patients has a genetic predisposition to autoimmunity.
|
20627832 |
2010 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, the DRB1*0901 haplotype and the risk alleles of ERBB3, CLEC16A and CTLA4 were positively associated with the co-occurrence of thyroid autoimmunity.
|
22069271 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Molecular studies showed a peculiar profile characterized by HLA class I genotype rich of ligands for natural killer cell immunoglobulin-like receptors (KIR) and HLA class II haplotype, HLA-DRB1*03:01,DQB1*02:01, prone to autoimmunity.
|
25359191 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.
|
19675171 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here we focused on one of the six HLA GWI-protective HLA alleles, DRB1*13:02, which has been found to have a protective role in a broad range of autoimmune diseases (Furukawa et al., 2017), and tested its effects on brain volumes.
|
29137891 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens.
|
18954286 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The monomodular-short haplotype with a single C4B gene and the absence of C4A, which is in linkage-disequilibrium with HLA DRB1*0301 in Europeans and a strong risk factor for autoimmune diseases, has a frequency of 0.012 in AIA but 0.106 among healthy European Americans (p=6.6x10(-8)).
|
19135723 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found no evidence for association of these variants with T1D overall, nor in subgroups of patients with or without the major risk genotypes at HLA-DRB1, at insulin (INS), or positive or negative for autoantibodies specific to other autoimmune diseases.
|
16198136 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines.
|
27435705 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The HLA DRB1*08032 allele was strongly associated with susceptibility to methimazole-induced agranulocytosis, suggesting that cellular autoimmunity may be involved in its development.
|
8602707 |
1996 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Conversely, native CII autoimmunity was not associated with any specific DRB1 allele.
|
23160643 |
2013 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We hypothesized that nonislet autoimmunity might be expressed in a similar manner in Korean as well as in Caucasian patients and correlated with the DRB1-DQB1 haplotypes.
|
15699495 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of HLA-DRB1 or HLA-DQB1 are related to production of AAs in autoimmune diseases.
|
21557256 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Besides the acknowledged correlation between the HLA-A*02 and HLA-B*15 alleles (as well as low birth weight) and type I diabetes and between the HLA-B*38 and HLA-DRB1*13 alleles (as well as high birth weight) and several autoimmune diseases, we cannot predict if our babies, healthy at birth, will suffer from these pathologies during life.
|
19500315 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Of identified genetic variants, HLA polymorphisms confer the greatest risk for developing autoimmune diseases, including rheumatoid arthritis (HLA-DRB1*04).
|
26091715 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus.
|
17936227 |
2007 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, taken together with our previous observations, the haplotype carrying DRB1*13:02 was suggested to be a shared protective factor against multiple autoimmune diseases.
|
27166610 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Due to the association with autoimmune diseases and proven application in population genetics, we aimed to investigate alleles of the Class II Human Leukocyte Antigens (HLA-DRB1) in the Mexican Mestizo population with aortic aneurysms and determine possible associations with susceptibility.
|
31174489 |
2019 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Particularly, the association in all Caucasian populations of an impressive number of autoimmune diseases with genes from the HLA-B8,DR3 haplotype that is part of the ancestral haplotype (AH) 8.1 HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201 has been reported by different research groups.
|
12849055 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, a genome-wide association study identified genetic variations in ITGA4 and HLA-DRB1 that affect the LMR levels and were widely believed to be susceptibility genes for autoimmune diseases, including rheumatoid arthritis (RA).
|
28913574 |
2017 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore examined the effect of HLA-DRB1*13 on: ACPA presence (systemic autoimmunity associated with RA) in individuals with and without RA, on ACPA characteristics and on clinical outcome measures.
|
26715653 |
2016 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
NCA-LEMS was strongly associated with DRB1*0301 (p<0.0001) and DQB1*0201 (p<0.0001), suggesting that NCA-LEMS is an autoimmune disorder associated with the DR3-DQ2 extended haplotype.
|
10980394 |
2000 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-GBM disease is caused by autoimmunity to Goodpasture antigen on α3(IV)NC1 and had strong associations with HLA-DRB1*1501.
|
28570922 |
2017 |