|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
While genome studies map a strong MS susceptibility effect to the region of DRB1*1501, our findings offer a rationale for potential involvement of pathogenic DQ6-associated autoimmunity in MS.
|
22316121 |
2012 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Both generalized and localized vitiligo have the same predisposing major histocompatibility complex alleles, i.e., B*44:03 and DRB1*07:01, in both the populations studied, beside the differences in the frequencies of other alleles, suggesting that localized vitiligo too may be an autoimmune disorder.
|
21833019 |
2012 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, stratified analyses indicated statistically significant associations between HLA-DRB1*04 allele and anti-cyclic peptides antibodies positivity (ACPA(+)) and rheumatoid factor positivity (RF(+); p(c)=0.03, for both subgroups), HLA-DRBI*10 and ACPA(+) and the presence of another autoimmune disease (p(c)=0.05 and p(c)=0.007, respectively), and HLA-DRB1*04:05 and RF(+) and erosion (p(c)=0.005 and p(c)=0.049; respectively).
|
22349877 |
2012 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The increased frequency of DRB1*07:01 in North Indian and Gujarat populations with generalized and localized vitiligo and in several vitiligo populations studied previously suggests that it contributes to autoimmunity and destruction of melanocytes.
|
22158608 |
2012 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It is well known that HLA-DRB1 genotypes have a strong influence on the risk of multifactorial autoimmune diseases, but the effect of CIITA genotypes remains controversial.
|
23777927 |
2013 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
|
23180817 |
2013 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, HLA-DRB1*09:01 has been shown to be associated with multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus, suggesting that either HLA-DRB1*09:01 itself or other genes in tight linkage disequilibrium may play a role in a molecular pathway shared by various autoimmune diseases in Japanese and possibly in other Asian populations.
|
23180035 |
2013 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
HLA-DRB1*11 had a significant risk for association with a family history of autoimmunity in autistic children (odds ratio: 5.67; 95% CI: 2.07-16.3).
|
23110937 |
2013 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Conversely, native CII autoimmunity was not associated with any specific DRB1 allele.
|
23160643 |
2013 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
HLA-DRB1*15 is a relevant MS susceptibility locus in the Italian population, possibly with little influence on the occurrence of concomitant autoimmune disorders.
|
23279712 |
2013 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases.
|
24430436 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The association of human autoimmune diseases with distinct HLA alleles is a well-known phenomenon, such as the association with HLA-DRB1*04:02 in PV.
|
25252957 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The HLA-DRB1 locus is known as the most important genetic contributor for the risk of RA, but is not sufficient to drive autoimmunity and additional genetic and environmental factors are involved.
|
25138370 |
2014 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
This mechanism could provide a robust synergistic action and a differential role of DRB1 and DQB1 in tissues and in the time-steps towards autoimmunity.
|
24853027 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Molecular studies showed a peculiar profile characterized by HLA class I genotype rich of ligands for natural killer cell immunoglobulin-like receptors (KIR) and HLA class II haplotype, HLA-DRB1*03:01,DQB1*02:01, prone to autoimmunity.
|
25359191 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies of isolated T1D and of T1D combined with other autoimmune disorders showed genetic susceptibility for alleles in HLA-DQB1 and -DRB1 and also CTLA4 and PTPN22.
|
26405068 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
On the basis of these results, the HLA alleles DRB1*0101 and DRB1*0404 and the PTPN22 R620W variant are consistently associated with autoimmunity in the T1DGC Autoantibody Workshop data.
|
26405072 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58).
|
26605347 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Additionally, the HLA class II (DRB1) of all the patients was genotyped, including an additional group of patients without the autoimmune disease.
|
26022697 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Of identified genetic variants, HLA polymorphisms confer the greatest risk for developing autoimmune diseases, including rheumatoid arthritis (HLA-DRB1*04).
|
26091715 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
To elucidate the optimal conditions for proinsulin-based PIT and explore mechanisms of action, we developed a preclinical model of proinsulin autoimmunity in a humanized HLA-DRB1*0401 transgenic HLA-DR4 Tg mouse.
|
26206289 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore examined the effect of HLA-DRB1*13 on: ACPA presence (systemic autoimmunity associated with RA) in individuals with and without RA, on ACPA characteristics and on clinical outcome measures.
|
26715653 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The effect of human lymphocyte antigen-DRB1 shared epitope alleles on autoantibody positivity was limited to RA patients who were exposed to Aa These studies identify the periodontal pathogen Aa as a candidate bacterial trigger of autoimmunity in RA.
|
27974664 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, taken together with our previous observations, the haplotype carrying DRB1*13:02 was suggested to be a shared protective factor against multiple autoimmune diseases.
|
27166610 |
2016 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-GBM disease is caused by autoimmunity to Goodpasture antigen on α3(IV)NC1 and had strong associations with HLA-DRB1*1501.
|
28570922 |
2017 |