|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Carriers of pathogenic variants had HLA-DRB1 risk alleles for autoimmune diabetes and clinical characteristics compatible with type 1 diabetes except for the absence of autoimmunity.
|
31365591 |
2019 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Due to the association with autoimmune diseases and proven application in population genetics, we aimed to investigate alleles of the Class II Human Leukocyte Antigens (HLA-DRB1) in the Mexican Mestizo population with aortic aneurysms and determine possible associations with susceptibility.
|
31174489 |
2019 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
DRB1*03:01-DQB1*02:01, the major T1D susceptibility haplotype, was found at a lower frequency in T1D patients with thyroid autoimmunity.
|
29383806 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The -1123G > C SNP in the PTPN22 gene promoter and HLA DRB1*0405-DQB1*0401 might influence the concurrence of systemic and organ-specific ADs in patients with type 1 diabetes.
|
29762907 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-GBM disease is caused by autoimmunity to Goodpasture antigen on α3(IV)NC1 and had strong associations with HLA-DRB1*1501.
|
28570922 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A gene dosage effect was observed in the associations of DRB1*13:02 with the protection from systemic autoimmune diseases; thus homozygous individuals are more effectively protected from the systemic autoimmune diseases than heterozygotes.
|
27829665 |
2017 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB1*01 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity.
|
28059022 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here we focused on one of the six HLA GWI-protective HLA alleles, DRB1*13:02, which has been found to have a protective role in a broad range of autoimmune diseases (Furukawa et al., 2017), and tested its effects on brain volumes.
|
29137891 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nonetheless, there are hundreds of polymorphisms of HLA-DRB1 which have been associated with different autoimmune disorders as well as with immune response to infection and vaccines.
|
27435705 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, a genome-wide association study identified genetic variations in ITGA4 and HLA-DRB1 that affect the LMR levels and were widely believed to be susceptibility genes for autoimmune diseases, including rheumatoid arthritis (RA).
|
28913574 |
2017 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore examined the effect of HLA-DRB1*13 on: ACPA presence (systemic autoimmunity associated with RA) in individuals with and without RA, on ACPA characteristics and on clinical outcome measures.
|
26715653 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The effect of human lymphocyte antigen-DRB1 shared epitope alleles on autoantibody positivity was limited to RA patients who were exposed to Aa These studies identify the periodontal pathogen Aa as a candidate bacterial trigger of autoimmunity in RA.
|
27974664 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, taken together with our previous observations, the haplotype carrying DRB1*13:02 was suggested to be a shared protective factor against multiple autoimmune diseases.
|
27166610 |
2016 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies of isolated T1D and of T1D combined with other autoimmune disorders showed genetic susceptibility for alleles in HLA-DQB1 and -DRB1 and also CTLA4 and PTPN22.
|
26405068 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
On the basis of these results, the HLA alleles DRB1*0101 and DRB1*0404 and the PTPN22 R620W variant are consistently associated with autoimmunity in the T1DGC Autoantibody Workshop data.
|
26405072 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58).
|
26605347 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Additionally, the HLA class II (DRB1) of all the patients was genotyped, including an additional group of patients without the autoimmune disease.
|
26022697 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Of identified genetic variants, HLA polymorphisms confer the greatest risk for developing autoimmune diseases, including rheumatoid arthritis (HLA-DRB1*04).
|
26091715 |
2015 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
To elucidate the optimal conditions for proinsulin-based PIT and explore mechanisms of action, we developed a preclinical model of proinsulin autoimmunity in a humanized HLA-DRB1*0401 transgenic HLA-DR4 Tg mouse.
|
26206289 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases.
|
24430436 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The association of human autoimmune diseases with distinct HLA alleles is a well-known phenomenon, such as the association with HLA-DRB1*04:02 in PV.
|
25252957 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The HLA-DRB1 locus is known as the most important genetic contributor for the risk of RA, but is not sufficient to drive autoimmunity and additional genetic and environmental factors are involved.
|
25138370 |
2014 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
group |
BEFREE |
This mechanism could provide a robust synergistic action and a differential role of DRB1 and DQB1 in tissues and in the time-steps towards autoimmunity.
|
24853027 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Molecular studies showed a peculiar profile characterized by HLA class I genotype rich of ligands for natural killer cell immunoglobulin-like receptors (KIR) and HLA class II haplotype, HLA-DRB1*03:01,DQB1*02:01, prone to autoimmunity.
|
25359191 |
2014 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It is well known that HLA-DRB1 genotypes have a strong influence on the risk of multifactorial autoimmune diseases, but the effect of CIITA genotypes remains controversial.
|
23777927 |
2013 |