Gene: ESR2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE Quantification of C-ERB-B2 gene amplification in breast cancer cells using fluorescence in situ hybridization and digital image analysis. 8616779 1996
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Expression of estrogen receptor beta messenger RNA variant in breast cancer. 9443393 1998
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients. 10554009 1999
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE To complement the RNA expression studies, we have developed ER-beta-specific antibodies to characterize ER-beta protein expression in breast cancer cell lines and tumors. 10554010 1999
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Detection of estrogen receptor-beta mRNA in breast cancer using RT-PCR. 10763153 2000
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE Prognostic significance of oestrogen receptor beta in breast cancer. 10759732 2000
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE Estrogen receptor beta in the breast: role in estrogen responsiveness and development of breast cancer. 11162931 2000
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 GeneticVariation disease BEFREE Quantitative analysis of estrogen receptor-beta mRNA and its variants in human breast cancers. 11072241 2000
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE We determined that ER-beta is expressed in normal and tumor human breast tissue as well as in breast cancer cell lines. 10601611 2000
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer. 10690532 2000
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Clinical value of the wild-type estrogen receptor beta expression in breast cancer. 11165756 2001
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE However, our data provide preliminary evidence that the expression of oestrogen receptor beta protein isoforms may differ in primary tumours of breast cancer patients who prove to have differential sensitivity to tamoxifen therapy. 12454770 2002
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Evaluation of oestrogen receptor beta wild-type and variant protein expression, and relationship with clinicopathological factors in breast cancers. 11818203 2002
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 GeneticVariation disease BEFREE In this first association study about breast cancer risk and polymorphisms in the ERbeta gene we have screened 219 Finnish sporadic breast cancer cases and 248 ethnically matched male controls. 12846425 2003
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 GeneticVariation disease BEFREE Our results are consistent with the hypothesis of a joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk. 14633679 2003
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Collectively, ERbeta mRNA decreases in the process of BC development, but seems to be associated with poor differentiation. 12889601 2003
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 PosttranslationalModification disease BEFREE Real-time polymerase chain reaction (PCR) was used to investigate the methylation status of the ER beta gene in the ER beta negative breast cancer cell lines SkBr3 and MDA-MB-435. 14517838 2003
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE Treatment of breast cancer cells with demethylating agent effectively reactivated the expression of ERbeta mRNA. 14576822 2003
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 GeneticVariation disease BEFREE Correlation of mRNA for oestrogen receptor beta splice variants ERbeta1, ERbeta2/ERbetacx and ERbeta5 with outcome in endocrine-treated breast cancer. 15591034 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. 14729654 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE We define several other haplotypes in Ashkenazi Jews in both ESR1 and ESR2 that may elevate susceptibility to breast cancer. 15604249 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE Prospective evaluation of estrogen receptor-beta in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients. 15613450 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE Estrogen receptor beta and breast cancer. 15522549 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 Biomarker disease BEFREE This study has confirmed the hypothesis that expression of ERalpha is an important determinant of breast cancer progression, and has further demonstrated that ERbeta1 may play a role in the response of breast cancers to endocrine therapy. 15477865 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.600 AlteredExpression disease BEFREE DNA methylation inhibitor, procainamide, may decrease the tamoxifen resistance by inducing overexpression of the estrogen receptor beta in breast cancer patients. 15325017 2004