Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells. 25990368 2016
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Because knockdown of fibronectin abrogated the disruptive proliferation caused by introduction of GALNT6 into epithelial cells, our findings suggest that GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression. 21472136 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices. 26447611 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Consistent with the reduced TWIST1 levels in breast cancer, reexpression of miR-720 upregulated epithelial markers (E-cadherin and β-catenin) and downregulated mesenchymal markers (N-cadherin, fibronectin, vimentin and matrix metalloproteinase-2). 24085799 2014
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Conversely, ectopic expression of TG2 augmented invasion of breast cancer cells and attachment to Fn-coated surfaces. 17043648 2007
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway. 23653350 2013
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Exposure of estrogen-independent MDA-MB-231 and estrogen-responsive MCF-7 human breast cancer cell lines and a pancreatic cancer cell line (PL-45) to BITC resulted in upregulation of epithelial markers (e.g., E-cadherin and/or occludin) with a concomitant decrease in protein levels of mesenchymal markers, including vimentin, fibronectin, snail, and/or c-Met. 21464039 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Forced expression of miR-7 produced increased E-CADHERIN and decreased FIBRONECTIN and VIMENTIN expression in breast cancer cells. 22876288 2013
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Gene expression profiling identifies Fibronectin 1 and CXCL9 as candidate biomarkers for breast cancer screening. 20068563 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Here, we show that GPER-1 stimulation of murine 4 T1 or human SKBR3 breast cancer cells with 17β-estradiol (E2β) promotes the formation of focal adhesions and actin stress fibers and results in increased cellular adhesion and haptotaxis on FN, but not collagen. 25096985 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Here, we show that LGALS3BP knockdown in MDA-MB-231 human breast cancer cells leads to a decreased adhesion to fibronectin, a reduced transendothelial migration and, more importantly, a reduced expression of vascular endothelial growth factor (VEGF). 22864925 2013
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Here, we study the effect of EGFR alone and in collaboration with fibronectin on the status of MMP-9 in human breast cancer cell MDA-MB-231 and its molecular mechanism; study the role of EGCG on the induced MMP-9; and elucidate the signaling molecules involved in the process. 21170718 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Herein, we found that SRC-1 deficiency in mouse and human breast cancer cells substantially reduced cell adhesion and migration capabilities on fibronectin and significantly extended the time of focal adhesion disassembly and reassembly. 21343398 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE In summary, our findings offer evidence that mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human breast cancer and melanoma cells. 20145126 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE In the current study, we investigated the relationship between FN induction and HER2 expression in breast cancer cells. 25743092 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE In this study, we evaluated the ability of ATN-161 (Ac-PHSCN-NH2), a 5-mer capped peptide derived from the synergy region of fibronectin that binds to alpha5beta1 and alphavbeta3 in vitro, to block breast cancer growth and metastasis. 16985061 2006
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE It is known that fibronectin is capable of promoting the expression of MMP-2 in MCF7 breast cancer cells in culture. 25208219 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025 2013
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 GeneticVariation disease BEFREE Migratory inhibition upon STAT5b knockdown could be rescued by reintroduction of wild-type STAT5b, as well as Y699F- and dominant-negative STAT5b mutants, but not an SH2 domain defective R618K-STAT5b mutant. beta1- integrin-mediated migration of breast cancer cells to fibronectin was inhibited with STAT5b knockdown, and loss of STAT5b correlated with loss of directional migration and formation of multiple, highly contractile protrusions upon attachment to fibronectin. 19630967 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Most importantly, siRNA-downregulation of hB7H3 reduced cell adhesion to fibronectin of melanoma and breast cancer cells by up to 50 %, and migration and matrigel-invasion by more than 70 %, but surprisingly had no apparent impact on cell proliferation. 18690846 2008
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Our findings offer preclinical validation of fibronectin and alpha5beta1-integrin as targets for breast cancer therapy. 20516121 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Our results suggest that GPR30 coordinates estrogen-mediated FN matrix assembly and growth factor release in human breast cancer cells via a Shc-dependent signaling mechanism that activates integrin alpha5beta1. 19342448 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Previous studies from our laboratory and others have demonstrated that treatment of breast cancer cells with exogenous maspin led to a significant decrease in cell motility, and an increase in cell adhesion to human fibronectin. 14508113 2004
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. 18243246 2008
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE RNA interference of endogenous PTHrP caused a significant reduction in cell adhesion of a breast cancer cell line to collagen type I, fibronectin and laminin (P<0.05) and of a colon cancer cell to collagen type I and fibronectin (P<0.05). 17406357 2007