| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | AlteredExpression | disease | BEFREE | We have recently reported the identification of a new oncogene, named PTC, frequently activated in human thyroid papillary carcinomas. | 1701232 | 1990 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. | 15145515 | 2004 | ||||
|
0.100 | Biomarker | disease | BEFREE | One papillary carcinoma (1.7%) was positive for ret/PTC-1, none was positive for ret/PTC-2, and 2(3.4%) were positive for ret/PTC-3. | 8784097 | 1996 | ||||
|
0.100 | Biomarker | disease | BEFREE | The frequency, if we consider exclusively the papillary carcinomas, is in both cases 12%; (b) show that the TRK oncogene plays a role in the development of a minority of radiation-associated papillary thyroid carcinomas but not in adenomas; and (c) confirm that RET/PTC rearrangements are the major genetic alteration associated with ionizing radiation-induced thyroid tumorigenesis. | 10646882 | 2000 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | BRAF and RAS mutations and RET/PTC gene rearrangements were found in 65.1%, 0%, and 1.6% of papillary carcinomas, respectively. | 24591770 | 2014 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | Furthermore, the PTC/retTPC chimeric transcripts were detected in two PCs with the rearrangement by reverse transcription polymerase chain reaction. | 1620547 | 1992 | ||||
|
0.100 | Biomarker | disease | BEFREE | In fact, it has been demonstrated that: a) RET/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the papillary carcinoma; b) RET/PTC activation is essentially restricted to the papillary histotype and to the Hürthle thyroid tumors; c) its incidence increases after exposure to radiations. | 17891236 | 2007 | ||||
|
0.100 | AlteredExpression | disease | LHGDN | Papillary carcinomas with high RET/PTC1 expression showed an association trend for large tumor size (P=0.063). | 15502856 | 2004 |