Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.010 GeneticVariation disease BEFREE It was found that the AA genotype of CASP8 rs13113 (T/A) was independently associated with increased risk for CTS. 31692049 2020
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
0.010 AlteredExpression disease BEFREE An Agilent miRNA microarray was used to profile miRNAs in the CTS-treated BMSCs and 3D-cultured control BMSCs. miR-365 was shown to interact with HDAC4 mRNA through a luciferase reporter assay. 31276691 2019
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.010 Biomarker disease BEFREE Endoscopic CTR with FDS opponensplasty provides satisfactory outcomes of improved thumb abduction and opposition, sensory and motor recovery, and early return to work in patients with severe CTS. 31072662 2019
Entrez Id: 3313
Gene Symbol: HSPA9
HSPA9
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 1442
Gene Symbol: CSH1
CSH1
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.010 Biomarker disease BEFREE Fibroblasts harvested from Dupuytren's disease (DD) and carpal tunnel (CT) tissues were cultured in the presence or absence of TGF-β1 (10 ng/ml) and/or PFD (800 μg/ml). 30927912 2019
Entrez Id: 1443
Gene Symbol: CSH2
CSH2
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 100526830
Gene Symbol: SLX1A-SULT1A3
SLX1A-SULT1A3
0.010 GeneticVariation disease BEFREE The CTS patients had the highest rates of repeat testing (19.5%) compared with patients with JP (1.4%) and STM (0%). 31677910 2019
Entrez Id: 6818
Gene Symbol: SULT1A3
SULT1A3
0.010 GeneticVariation disease BEFREE The CTS patients had the highest rates of repeat testing (19.5%) compared with patients with JP (1.4%) and STM (0%). 31677910 2019
Entrez Id: 1161
Gene Symbol: ERCC8
ERCC8
0.010 Biomarker disease BEFREE Patients with DM and CTS had a slightly enlarged median nerve CSA than did patients with only CTS, but the difference was not statistically significant (0.52 mm<sup>2</sup>, 95% CI - 0.54 to 1.59). 30805796 2019
Entrez Id: 445329
Gene Symbol: SULT1A4
SULT1A4
0.010 GeneticVariation disease BEFREE The CTS patients had the highest rates of repeat testing (19.5%) compared with patients with JP (1.4%) and STM (0%). 31677910 2019
Entrez Id: 268
Gene Symbol: AMH
AMH
0.010 Biomarker disease BEFREE Carpal tunnel was related to dialysis vintage and MIS. 31546847 2019
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
0.010 AlteredExpression disease BEFREE But, PFD significantly decreased the TGF- β1-induced phosphorylation levels of ERK1/2 in both CT- and DD- cells. 30927912 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.010 Biomarker disease BEFREE We show that the TGF-β1-induced phosphorylation of AKT was significantly decreased by the addition of PFD (800 μg/mL) in both CT- and DD-derived fibroblasts. 30927912 2019
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.010 AlteredExpression disease BEFREE Expression of vitamin D receptor in the subsynovial connective tissue in women with carpal tunnel syndrome. 29329504 2018
Entrez Id: 56994
Gene Symbol: CHPT1
CHPT1
0.010 Biomarker disease BEFREE METHODS The authors utilized the PearlDiver database to identify the number of individuals with CTS in the Medicare patient population, and then utilized CPT codes to identify which individuals underwent surgical management. 29712517 2018
Entrez Id: 2047
Gene Symbol: EPHB1
EPHB1
0.010 Biomarker disease BEFREE We used multivariable Cox proportional hazards regression models to describe exposure-disease associations for incident CTS for individually observed physical exposures and JEM exposures from O*NET. 29599164 2018
Entrez Id: 406899
Gene Symbol: MIR106A
MIR106A
0.010 AlteredExpression disease BEFREE We found that CTS significantly promoted miR-106a-5p expression in chondrocytes. 29858052 2018
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
0.010 GeneticVariation disease BEFREE Our findings showed that there are no associations of IL-1Ra and ACE I/D polymorphisms with susceptibility of a person for the development of CTS. 28370589 2018
Entrez Id: 4907
Gene Symbol: NT5E
NT5E
0.010 Biomarker disease BEFREE The ENT commitment is therefore to suspect MPS when non-specific ENT pathologies are associated with repeated surgical treatments, unexplainable worsening of diseases despite correct treatment, and with signs, symptoms, and pathological conditions such as hepatomegaly, inguinal hernia, macrocephaly, macroglossia, coarse facial features, hydrocephalous, joint stiffness, bone deformities, valvular cardiomyopathy, carpal tunnel syndrome, and posture and visual disorders. 30442170 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.010 Biomarker disease BEFREE Studies have described an increase in the expression of growth factors, including Transforming Growth Factor (TGF-β), Vascular Endothelial Growth Factor (VEGF) and interleukins (growth factors for immune and inflammatory cells) in SSCT (sub-synovial connective tissue) in CTS patients. 30125568 2018
Entrez Id: 54437
Gene Symbol: SEMA5B
SEMA5B
0.010 Biomarker disease BEFREE The CMAP and sEMG epochs obtained at different levels of muscle activation from (1) the abductor pollicis brevis (APB) muscle of persons with and without a carpal tunnel syndrome (CTS) and (2) from a computer model of sEMG generation previously published were analysed. 29424359 2018
Entrez Id: 1055
Gene Symbol: CECR
CECR
0.010 GeneticVariation disease BEFREE Bivariate and multivariable regression analyses were performed to determine whether the variance of CES-D and PASS scores are associated with the variance of symptom severity or functional disability of CTS patients. 29305236 2018
Entrez Id: 6406
Gene Symbol: SEMG1
SEMG1
0.010 Biomarker disease BEFREE The CMAP and sEMG epochs obtained at different levels of muscle activation from (1) the abductor pollicis brevis (APB) muscle of persons with and without a carpal tunnel syndrome (CTS) and (2) from a computer model of sEMG generation previously published were analysed. 29424359 2018
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.010 AlteredExpression disease BEFREE Taken together the inhibition of TβRI appears to be the primary mediator of fibrotic gene expression in fibroblasts from CTS patients. 28294324 2018