HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Conspicuous frequencies of the alleles associated with susceptibility to CD were observed (DQA1*0501: 0.592, DQB1*0201: 0.471).
|
15120190 |
2004 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA in coeliac disease families: a novel test of risk modification by the 'other' haplotype when at least one DQA1*05-DQB1*02 haplotype is carried.
|
12392509 |
2002 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Celiac disease (CD) is associated with tissue transglutaminase autoantibodies (tTGAs) in individuals carrying the human leukocyte antigen (HLA) risk haplotypes DQA1*05:01-DQB1*02:01 (DQ2) and/or DQA1*03:01-DQB1*03:02 (DQ8).
|
26301618 |
2016 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD).
|
31331105 |
2019 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We like to suggest that the haplotype HLA-DQA1*03-DQB1*03:03 (HLA-DQ9.3), which is common in Chinese, is a new susceptibility factor for CD in China.
|
26496305 |
2015 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four modified sequence specific primers (SSP) pairs were designed for the selective amplification of coeliac disease associated alleles (DQA1*05, DQB1*02, DQB1*03:02 alleles), and human growth hormone (positive control).
|
26043316 |
2015 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the HLA-DQA1 and DQB1 alleles in 55 Turkish children with celiac disease and 50 control subjects was investigated by using an allele-specific DNA-based polymerase chain reaction-sequence-specific primer (PCR-SSP) method.
|
11556984 |
2001 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively reviewed the medical records of 127 consecutive cases of adult-onset celiac disease evaluated at a single United States center to determine the distribution of the associated human leukocyte antigen DQA1 and DQB1 alleles.
|
21292306 |
2011 |
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have recently reported that the susceptibility to develop celiac disease (CD) seems to be primarily associated to a particular combination of an HLA-DQA1 (DQA1*0501) and an HLA-DQB1 (DQB1*0201) allele: i.e., a particular DQ alpha/beta heterodimer.
|
1980918 |
1990 |
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The presence of the DQ2 (DQA1*0501/DQB1*02) heterodimer is strongly associated with celiac disease in the population studied by the authors.
|
14581805 |
2003 |
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results show that HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 alleles conferred susceptibility to CD in Brazilian patients.
|
11045836 |
2000 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the DQA1*0501 allele did not have a significant association with the severity of CD.
|
16484124 |
2006 |
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied nine consecutive DQ2-negative celiacs [from a group of 186 consecutive celiac disease (CD) patients] for the presence of the HLA-DQB1, DRB1, and DRBx alleles.
|
11061289 |
2000 |
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because of rarely reported cases of CD/rhabdomyolysis, anti-tissue transglutaminase (tTG) antibodies were measured and found positive (IgA 34 U/mL, unv <9).HLA typing was DQA1 05:02, DQB1 03:02.
|
28606713 |
2018 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic susceptibility of celiac disease is primarily associated with a particular combination of and HLA-DQA1/DQB1 gene; however, this does not fully account for the genetic predisposition.
|
8253354 |
1993 |
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study we analysed this population to evaluate the degree of association with CD of the haplotypes and genotypes at the main HLA-DQB1 and DQA1 disease loci.
|
11929591 |
2001 |
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As expected, all CD patients had at least one of the CD-associated alleles, and the highest CD risk was indicated by the presence of the HLA-DQ2.5 heterodimer (HLA-DQA1*05-DQB1*02) with HLA-DQB1*02 in homozygosity.
|
25413104 |
2014 |
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate a possible correlation between the HLA-DQA1 and HLA-DQB1 genetic markers and clinical features of celiac disease.
|
12050583 |
2002 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals homozygous for DQ2 or heterozygous for DQA1*05-DQB1*02/DQA1*0201-DQB1*02 were found to be at five-fold increased risk for development of coeliac disease (P<10(-8)).
|
15014431 |
2004 |
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic predisposition to celiac disease (CD) is determined primarily by the human leukocyte antigen (HLA) genes (CELIAC1 region; 6p21), although many loci are involved in disease susceptibility.
|
17767555 |
2007 |
HLA-DQA1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Less frequently, CD occurs in individuals positive for the DQ2.x heterodimers (DQA1≠*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers.
|
23050549 |
2012 |
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing.
|
23050549 |
2012 |
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic predisposition to coeliac disease (CD) is determined primarily by alleles at the HLA-DQB locus, and evidence exists implicating other major histocompatibility complex-linked genes (6p21) and the CTLA4 locus on chromosome 2q33.
|
15713213 |
2005 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene.
|
2909659 |
1989 |
HLA-DQA1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
celiac disease is associated with the HLA class II alleles: DQA1*05-DQB1*02 and DQB1*0302.
|
24274444 |
2013 |