|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The genetic predisposition at the HLA-DQB1 locus influences the severity of the mucosal damage in a dose-dependent manner, but not the clinical presentation, of celiac disease.
|
17190762 |
2007 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The heterodimer HLA-DQB1*0201/-DQA1*0501, present in 96% of our patients, is strongly associated with CD susceptibility, confirming published reports.
|
8590546 |
1995 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The highest HLA-DQB risk for CD development was found in patients carriers a DQ2.5/DQ8 genotype (1/10), followed by the patients carriers DQ2.5/DQ2.5 (1/12).
|
29793442 |
2018 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The proportion of clinically undetected celiac disease may be particularly high among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 HLA-risk alleles frequently occur.
|
19915493 |
2010 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A.
|
16567828 |
2006 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results show that HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 alleles conferred susceptibility to CD in Brazilian patients.
|
11045836 |
2000 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that clinically suspected individuals for CD and first-degree relatives of patients with CD to be screened for HLA-DQB*0201 and DQB*0302 alleles for possible early diagnosis and treatments.
|
24917237 |
2014 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the contribution of HLA-DQA1* and HLA-DQB1* genes to the risk of coeliac disease (CD) in a cohort of children with type 1 diabetes mellitus (T1DM) from northern Italy.
|
15174785 |
2004 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Type 1 ETL also appears to be linked pathogenetically to celiac disease, sharing genetic alterations and HLA-DQB1 genotype patterns with (refractory) celiac disease.
|
17484883 |
2007 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found the prevalence of coeliac disease among siblings of children with Type I diabetes to be similar to figures reported from recent population-based studies and to be correlated with the prevalence of coeliac disease associated HLA-DQB1 alleles.
|
11484084 |
2001 |
|
HLA-DQB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have recently reported that the susceptibility to develop celiac disease (CD) seems to be primarily associated to a particular combination of an HLA-DQA1 (DQA1*0501) and an HLA-DQB1 (DQB1*0201) allele: i.e., a particular DQ alpha/beta heterodimer.
|
1980918 |
1990 |
|
HLA-DQB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied nine consecutive DQ2-negative celiacs [from a group of 186 consecutive celiac disease (CD) patients] for the presence of the HLA-DQB1, DRB1, and DRBx alleles.
|
11061289 |
2000 |