Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 60
Gene Symbol: ACTB
ACTB 		0.010 AlteredExpression disease BEFREE Cytoskeletal changes initiated following cocaine abuse are regulated by the Rho family of GTPases with significant downstream activity in key actin binding proteins. 30623590 2019
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A 		0.310 Biomarker disease PSYGENET Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. 23849431 2013
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A 		0.310 GeneticVariation disease BEFREE Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. 23849431 2013
Entrez Id: 27161
Gene Symbol: AGO2
AGO2 		0.300 Biomarker disease CTD_human Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. 20643829 2010
Entrez Id: 255239
Gene Symbol: ANKK1
ANKK1 		0.310 Biomarker disease BEFREE ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. 23635803 2013
Entrez Id: 255239
Gene Symbol: ANKK1
ANKK1 		0.310 Biomarker disease PSYGENET ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. 23635803 2013
Entrez Id: 23780
Gene Symbol: APOL2
APOL2 		0.300 Biomarker disease CTD_human Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. 17205118 2006
Entrez Id: 23237
Gene Symbol: ARC
ARC 		0.300 Biomarker disease CTD_human Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. 18311559 2008
Entrez Id: 374868
Gene Symbol: ATP9B
ATP9B 		0.300 Biomarker disease CTD_human Substance dependence low-density whole genome association study in two distinct American populations. 18438686 2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. 20971807 2011
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Biomarker disease BEFREE In developing an vivo drug-interception therapy to treat cocaine abuse and hinder relapse into drug seeking provoked by re-encounter with cocaine, two promising agents are: (1) a cocaine hydrolase enzyme (CocH) derived from human butyrylcholinesterase and delivered by gene transfer; (2) an anti-cocaine antibody elicited by vaccination. 22935511 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase. 25814464 2015
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. 22935511 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Biomarker disease BEFREE We are investigating treatments for cocaine abuse based on viral gene transfer of a cocaine hydrolase (CocH) derived from human butyrylcholinesterase, which can reduce cocaine-stimulated locomotion and cocaine-primed reinstatement of drug-seeking behavior in rats for many months. 22960160 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity. 23000451 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. 22960160 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 AlteredExpression disease BEFREE The available PET data imply that an effective therapeutic enzyme for treatment of cocaine abuse could be an exogenous cocaine-metabolizing enzyme with a catalytic activity against (-)-cocaine comparable to that of wild-type BChE against (+)-cocaine. 22917637 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. 18514640 2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Biomarker disease BEFREE Hence, viral gene transfer of BChE appears benign and worth exploring as a therapy for cocaine abuse and possibly other disorders as well. 24892251 2014
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction. 18292872 2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE 		0.340 Therapeutic disease CTD_human Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. 20060817 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.310 Therapeutic disease CTD_human MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. 20711185 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.310 Therapeutic disease CTD_human Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine. 20810894 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.310 Biomarker disease CTD_human Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. 18311559 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.310 Biomarker disease CTD_human Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. 17618281 2007